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Autor:
Qing Liu, Michael S. Gold
Publikováno v:
Anesthesiology. 125:755-764
BackgroundPrevious evidence suggests that opioid-tolerant patients are less responsive to local anesthetics (LAs) for postoperative pain management.MethodsTo determine whether this apparent loss of LA potency is due to an intrinsic change in the peri
Publikováno v:
Anesthesiology. 114:135-149
Background Postoperative pain can occur despite nerve blocks during the surgical period. Here we tested Xybrex (Orthocon, Inc., Irvington, NY), a slow-release formulation of lidocaine that blocks rat sciatic nerve for 1-2 days, for its ability to sup
Publikováno v:
Anesthesiology. 108:921-928
Background Sustained release of local anesthetics is frequently associated with myotoxicity. The authors investigated the role of particulate delivery systems and of the pattern of drug release in causing myotoxicity. Methods Rats were given sciatic
Autor:
Peter Gerner, Yi-Chuan Kau, Philipp Lirk, Robert R. Myers, I. Haller, Yu-Chun Hung, Lars Klimaschewski
Publikováno v:
Anesthesiology, 104(6), 1266-1273. Lippincott Williams and Wilkins
Background Local anesthetic-induced direct neurotoxicity (paresthesia, failure to regain normal sensory and motor function) is a potentially devastating complication of regional anesthesia. Local anesthetics activate the p38 mitogen-activated protein
Autor:
Peter Gerner, Thomas Edrich, Robert R. Myers, David Zurakowski, Ging Kuo Wang, Anthony M. Zizza, Yu-Chun Hung, Yi-Chuan Kau
Publikováno v:
Anesthesiology. 103:1246-1252
Background The sympathomimetic drug ephedrine has been used intrathecally as the sole local anesthetic for labor and delivery. Because ephedrine may be a useful adjuvant to local anesthetics, the authors investigated the local anesthetic properties o
Autor:
Mustafa Mujtaba, Anna E. Haderer, Ging Kuo Wang, Yukari Sudoh, Sanjeet Narang, C. Pertl, Salahadin Abdi, Peter Gerner, Venkatesh Srinivasa
Publikováno v:
Anesthesiology. 98:1484-1490
Background Increasing the duration of local anesthesia and/or creating greater differential blockade (i.e., selective block of pain-transmitting nerve fibers) has been attempted by modifying currently available agents. Most drugs show a different pro
Publikováno v:
Anesthesiology. 98:203-208
Background Systemic lidocaine and other local anesthetics reduce hypersensitivity states induced by both acute inflammation and peripheral nerve injury in animals and produce analgesia in some patients with chronic pain. The mechanisms underlying the
Publikováno v:
Anesthesiology. 98:181-188
Background Adding epinephrine to lidocaine solutions for peripheral nerve block potentiates and prolongs the action, but by incompletely understood mechanisms. In an effort to discriminate the pharmacokinetic from the pharmacodynamic effects of epine
Publikováno v:
Anesthesiology. 95:1198-1204
Background Local anesthetics that produce analgesia of long duration with minimal impairment of autonomic functions are highly desirable for pain management in the clinic. Prenylamine is a known calcium channel blocker, but its local anesthetic block
Publikováno v:
Anesthesiology. 94:661-667
Background Amitriptyline, a tricyclic antidepressant, is frequently used orally for the management of chronic pain. To date there is no report of amitriptyline producing peripheral nerve blockade. The authors therefore investigated the local anesthet