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Autor:
Steven Mcguigan, Will Woods, David T. J. Liley, Suresh D. Muthukumaraswamy, Levin Kuhlmann, Andria Pelentritou, John R. Cormack
Publikováno v:
Anesthesiology. 132:1017-1033
Background Investigations of the electrophysiology of gaseous anesthetics xenon and nitrous oxide are limited revealing inconsistent frequency-dependent alterations in spectral power and functional connectivity. Here, the authors describe the effects
Autor:
Froukje H. Knotnerus, Ernesto R R Muskiet, Martine Oostra, Jan Van Bocxlaer, Michel Struys, Maud A S Weerink, Koen Reyntjens, Pieter Colin, Clemens R M Barends
Publikováno v:
Anesthesiology, 131(5), 1004-1017. LIPPINCOTT WILLIAMS & WILKINS
WHAT WE ALREADY KNOW ABOUT THIS TOPIC: Patients sedated with standard clinical doses of dexmedetomidine can be readily arousedDexmedetomidine doses producing mild to deep sedation lack significant analgesic effectRemifentanil is an opioid analgesic w
Autor:
Jennifer H. Walsh, Malin Jonsson Fagerlund, Mika Scheinin, David R. Hillman, Åse Lodenius, Kathleen J. Maddison, Brad K. Lawther, Lars Eriksson, Peter R. Eastwood
Publikováno v:
Anesthesiology. 131:962-973
Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Dexmedetomidine is a sedative promoted as having minimal impact on ventilatory drive or upper airway muscle activity. However, a trial rece
Autor:
Oliver Bagshaw, Brian J. Anderson
Publikováno v:
Anesthesiology. 131:164-185
Propofol administered in conjunction with an opioid such as remifentanil is used to provide total intravenous anesthesia for children. Drugs can be given as infusion controlled manually by the physician or as automated target-controlled infusion that
Publikováno v:
Anesthesiology. 124:598-607
BackgroundSedation is commonly used in neurosurgical patients but has been reported to produce transient focal neurologic dysfunction. The authors hypothesized that in patients with frontal–parietal–temporal brain tumors, focal neurologic deficit
Publikováno v:
Anesthesiology. 121:1203-1216
Background: Cyclopropyl-methoxycarbonyl metomidate (CPMM, also known as ABP-700) is a second-generation “soft” (i.e., metabolically labile) etomidate analogue. The purpose of this study was to characterize CPMM’s pharmacology in beagle dogs in
Autor:
Martin Luginbühl, Laura N. Hannivoort, Michel Struys, Hugo Vereecke, Johannes H. Proost, Bjorn Heyse, Douglas J. Eleveld
Publikováno v:
Anesthesiology. 120:1390-1399
Background: The authors studied the interaction between sevoflurane and remifentanil on bispectral index (BIS), state entropy (SE), response entropy (RE), Composite Variability Index, and Surgical Pleth Index, by using a response surface methodology.
Autor:
Alexander S. Clanachan, Lukas Bestmann, Eliana Lucchinetti, Barry A. Finegan, Michael Zaugg, Jianhua Feng, Heike Freidank
Publikováno v:
Anesthesiology. 116:296-310
Background Two preconditioning stimuli should induce a more consistent overall cell protection. We hypothesized that remote ischemic preconditioning (RIPC, second preconditioning stimulus) applied during isoflurane inhalation (first preconditioning s
Publikováno v:
Anesthesiology. 116:47-55
Background Propofol produces its major actions via γ-aminobutyric acid type A (GABA(A)) receptors. At low concentrations, propofol enhances agonist-stimulated GABA(A) receptor activity, and high propofol concentrations directly activate receptors. E
Autor:
Jeremy M. Kahn, Andrew A. Kramer, Robert N. Sladen, Gordon D. Rubenfeld, Hannah Wunsch, Gebhard Wagener, Guohua Li
Publikováno v:
Anesthesiology. 113:386-394
Background Dexmedetomidine is a novel sedative agent that causes anxiolysis without respiratory depression in critically ill patients. We sought to examine patient and hospital variation in dexmedetomidine use and adoption patterns of dexmedetomidine