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Autor:
Reine Ibala, Shubham Chamadia, Oluwaseun Akeju, Jennifer Mekonnen, Jason Z. Qu, Eunice Hahm, Juan C Pedemonte, Joseph J. Locascio, Jacob Gitlin, Katia M Colon, Breanna R Ethridge
Publikováno v:
Anesthesiology. 133:1021-1028
Background Ketamine is a dissociative anesthetic with analgesic properties. Ketamine’s analgesic properties have been suggested to result from its dissociative properties. To the authors’ knowledge, this postulate is unsubstantiated. The authors
Publikováno v:
Anesthesiology
BackgroundAnesthetics aim to prevent memory of unpleasant experiences. The amygdala and dorsal anterior cingulate cortex participate in forging emotional and valence-driven memory formation. It was hypothesized that this circuitry maintains its role
Publikováno v:
Anesthesiology. 124:598-607
BackgroundSedation is commonly used in neurosurgical patients but has been reported to produce transient focal neurologic dysfunction. The authors hypothesized that in patients with frontal–parietal–temporal brain tumors, focal neurologic deficit
Publikováno v:
Anesthesiology. 113:429-437
Background Substantia gelatinosa of the spinal dorsal horn is crucial for transmission and modification of noxious stimuli. Previous studies have demonstrated that intrathecal midazolam, a benzodiazepine agonist, enhanced perioperative analgesia. Not
Autor:
Jeremy M. Kahn, Andrew A. Kramer, Robert N. Sladen, Gordon D. Rubenfeld, Hannah Wunsch, Gebhard Wagener, Guohua Li
Publikováno v:
Anesthesiology. 113:386-394
Background Dexmedetomidine is a novel sedative agent that causes anxiolysis without respiratory depression in critically ill patients. We sought to examine patient and hospital variation in dexmedetomidine use and adoption patterns of dexmedetomidine
Publikováno v:
Anesthesiology. 108:122-129
Background The significant postnatal maturation of gamma-aminobutyric acid signaling in the developing brain is likely to have important implications for infant pain processing. Gamma-aminobutyric acid receptor activation evokes analgesia and sedatio
Autor:
Anna I. Hårdemark Cedborg, Richard Kuylenstierna, Olle Ekberg, Katarina Bodén, Eva Sundman, Hanne Witt Hedström, Lars Eriksson
Publikováno v:
Anesthesiology. 122(6)
Background: Drugs used for sedation in anesthesia and intensive care may cause pharyngeal dysfunction and increased risk for aspiration. In this study, the authors investigate the impact of sedative doses of morphine and midazolam on pharyngeal funct
Publikováno v:
Anesthesiology. 105:764-778
Background Anesthetic endpoints of unconsciousness and immobility result from agent effects on both brain and spinal cord that are difficult to separate during systemic administration. To investigate cerebral mechanism of anesthetic-induced unconscio
Autor:
Sang Mook Lee, Gang Min Hur, Sang Ki Lee, Seon Nyo Kim, Cuk-Seong Kim, Dae Goon Yoo, Soo Chang Son, Byeong Hwa Jeon, Jin Bong Park
Publikováno v:
Anesthesiology. 105:105-110
Background Midazolam, a benzodiazepine, has a hypnotic effect and is widely used as a sedative. The role of midazolam in activation of macrophages during sepsis is not known. The aim of this study was to evaluate the antiinflammatory actions of midaz
Autor:
Suzanne Karan, Denham S. Ward, Linda Palmer, Anna Varlese, Peter L. Bailey, J. Russell Norton, William A. Voter, Ori Rackovsky
Publikováno v:
Anesthesiology. 104:1155-1164
Background Upper airway obstruction (UAO) during sedation can often cause clinically significant adverse events. Direct comparison of different drugs' propensities for UAO may improve selection of appropriate sedating agents. The authors used the app