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Autor:
Jacob Raphael, Eduard Berenshtein, Mordechai Chevion, Benjamin Drenger, Yaacov Gozal, Julia Rivo
Publikováno v:
Anesthesiology. 105(1)
Background The goal of the current study was to assess the effects of flumazenil, a benzodiazepine receptor antagonist, in limiting infarct size and in reducing hydroxyl free radical production. Methods After intravenous salicylate (100 mg/kg) admini
Publikováno v:
Anesthesiology. 104(2)
Background Although intrathecal administration of midazolam, a water-soluble imidazobenzodiazepine derivative, has been found to produce analgesia, how it exerts this effect at the neuronal level in the spinal cord is not fully understood. Methods Th
Autor:
Rick Fox, Gareth L. Ackland
Publikováno v:
Anesthesiology. 103(3)
Publikováno v:
Anesthesiology. 102(3)
Background Recent molecular strategies demonstrated that the N-methyl-d-aspartate (NMDA) receptor is a major target site of anesthetic agents. In a previous article, the authors showed that knocking out the NMDA receptor epsilon1 subunit gene markedl
Autor:
Albert Dahan, Bart Jan Lichtenbelt, Anton G. L. Burm, Jenny Vieveen, Frank H. M. Engbers, Jaap Vuyk
Publikováno v:
Anesthesiology. 100(1)
THE Bispectral Index (BIS) is increasingly used to monitor the level of (un)consciousness during surgical anesthesia and conscious sedation. Generally, an intraoperative BIS of 40-60 is considered sufficient to maintain adequate hypnosis for surgery.
Autor:
Mitsuko Hashiguchi, Kazuhiko Fukuda, Masami Sato, Nobuo Uetsuki, Hisatoshi Uga, Taizo Hisano, Yasumasa Iwasaki, Hajime Segawa
Publikováno v:
Anesthesiology. 98(5)
Background Benzodiazepines are frequently used not only as a part of general anesthesia but also for the purpose of sedation during regional anesthesia. Effects of these drugs on the hypothalamic-pituitary-adrenal axis activity have been studied, but
Publikováno v:
Anesthesiology. 96(5)
Background Postoperative nausea and vomiting (PONV) is still common, especially among female patients. Our hypothesis is that coinduction with clonidine reduces the incidence of PONV in adult patients undergoing breast cancer surgery. Methods Sixty-e
Publikováno v:
Anesthesiology. 96(4)
Background Although tests of psychomotor function indicate that drug effects after ambulatory anesthesia are short-lived, patients often feel washed out for long periods of time. Among the psychomotor tests that measure different motor and cognitive
Autor:
Peter L. Bailey, Alan R. Schwartz, Denham S. Ward, Matthew Basco, Ronald S. Litman, Jennifer L. Hayes
Publikováno v:
Anesthesiology. 96(2)
Background Traditional methods of assessing ventilatory effects of sedative agents do not measure their propensity to cause upper airway obstruction (UAO). The primary objective of this study was to develop a method, using dynamic negative airway pre
Publikováno v:
Anesthesiology. 95(5)
Background Bispectral Index (BIS) has been used to measure sedation depth. Ideally, to guide anesthetic management, range of BIS scores at different sedation levels should not overlap, and BIS should be independent of drug used. This study assessed a