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Publikováno v:
Anesthesiology. 124:598-607
BackgroundSedation is commonly used in neurosurgical patients but has been reported to produce transient focal neurologic dysfunction. The authors hypothesized that in patients with frontal–parietal–temporal brain tumors, focal neurologic deficit
Autor:
Jeremy M. Kahn, Andrew A. Kramer, Robert N. Sladen, Gordon D. Rubenfeld, Hannah Wunsch, Gebhard Wagener, Guohua Li
Publikováno v:
Anesthesiology. 113:386-394
Background Dexmedetomidine is a novel sedative agent that causes anxiolysis without respiratory depression in critically ill patients. We sought to examine patient and hospital variation in dexmedetomidine use and adoption patterns of dexmedetomidine
Publikováno v:
Anesthesiology. 105:764-778
Background Anesthetic endpoints of unconsciousness and immobility result from agent effects on both brain and spinal cord that are difficult to separate during systemic administration. To investigate cerebral mechanism of anesthetic-induced unconscio
Autor:
Suzanne Karan, Denham S. Ward, Linda Palmer, Anna Varlese, Peter L. Bailey, J. Russell Norton, William A. Voter, Ori Rackovsky
Publikováno v:
Anesthesiology. 104:1155-1164
Background Upper airway obstruction (UAO) during sedation can often cause clinically significant adverse events. Direct comparison of different drugs' propensities for UAO may improve selection of appropriate sedating agents. The authors used the app
Publikováno v:
Anesthesiology. 97:447-453
Background The effects of propofol on memory for aversive information are not well determined. The authors evaluated the effects of a minimal nonsedative dose of propofol or midazolam on memory in rats, using an apparatus composed of two compartments
Publikováno v:
Anesthesiology. 96:196-201
Background The goal of the current study was to evaluate the economic impact of propofol as compared with midazolam for sedating patients in the intensive care unit (ICU). Methods A randomized, unblinded, multicenter pharmacoeconomic trial captured h
Publikováno v:
Anesthesiology. 95:896-907
Background Sedative-hypnotic drugs not only increase sedation, but also impair memory as serum concentration increases. These drugs also produce profound changes in the auditory event-related potential (ERP). The ability of various ERP components to
Publikováno v:
Anesthesiology. 89:1444-1454
Background Clinical studies suggest that midazolam and propofol interact synergistically to induce hypnosis, but these drugs do not interact synergistically to prevent movement in response to noxious stimuli. The mechanisms underlying these interacti
Publikováno v:
Anesthesiology. 89:838-843
Background Controversy exists regarding the effectiveness of propofol to prevent postoperative nausea and vomiting. This prospective, randomized, single-blinded study was designed to evaluate the antiemetic effectiveness of 0.5 mg/kg propofol when ad
Autor:
John Howse, Wayne H. Bellows, Steven L. Shafer, Dennis T. Mangano, G. Roach, Ahvie Herskowitz, John Reeves, Long Ngo, J. Jerill Plunkett
Publikováno v:
Anesthesiology. 86:785-796
Background Cardiopulmonary bypass is associated with substantial release of catecholamines and cortisol for 12 or more h. A technique was assessed that may mitigate the responses with continuous 12-h postoperative sedation using propofol. Methods One