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Autor:
Froukje H. Knotnerus, Ernesto R R Muskiet, Martine Oostra, Jan Van Bocxlaer, Michel Struys, Maud A S Weerink, Koen Reyntjens, Pieter Colin, Clemens R M Barends
Publikováno v:
Anesthesiology, 131(5), 1004-1017. LIPPINCOTT WILLIAMS & WILKINS
WHAT WE ALREADY KNOW ABOUT THIS TOPIC: Patients sedated with standard clinical doses of dexmedetomidine can be readily arousedDexmedetomidine doses producing mild to deep sedation lack significant analgesic effectRemifentanil is an opioid analgesic w
Publikováno v:
Anesthesiology. 124:598-607
BackgroundSedation is commonly used in neurosurgical patients but has been reported to produce transient focal neurologic dysfunction. The authors hypothesized that in patients with frontal–parietal–temporal brain tumors, focal neurologic deficit
Publikováno v:
Anesthesiology. 121:1203-1216
Background: Cyclopropyl-methoxycarbonyl metomidate (CPMM, also known as ABP-700) is a second-generation “soft” (i.e., metabolically labile) etomidate analogue. The purpose of this study was to characterize CPMM’s pharmacology in beagle dogs in
Autor:
Jeremy M. Kahn, Andrew A. Kramer, Robert N. Sladen, Gordon D. Rubenfeld, Hannah Wunsch, Gebhard Wagener, Guohua Li
Publikováno v:
Anesthesiology. 113:386-394
Background Dexmedetomidine is a novel sedative agent that causes anxiolysis without respiratory depression in critically ill patients. We sought to examine patient and hospital variation in dexmedetomidine use and adoption patterns of dexmedetomidine
Autor:
Martin Luginbühl, Thomas Bouillon, Peter M. Schumacher, Pascal Henri Vuilleumier, Hugo Vereecke, Bjorn Heyse, Michel Struys
Publikováno v:
Anesthesiology. 112:872-880
Background The noxious stimulation response index (NSRI) is a novel anesthetic depth index ranging between 100 and 0, computed from hypnotic and opioid effect-site concentrations using a hierarchical interaction model. The authors validated the NSRI
Autor:
Jack Chen, Hugh Wolfenden, Yahya Shehabi, Naomi E Hammond, Frances Bass, Peter Grant, Michelle Campbell
Publikováno v:
Anesthesiology. 111:1075-1084
Background Commonly used sedatives/analgesics can increase the risk of postoperative complications, including delirium. This double-blinded study assessed the neurobehavioral, hemodynamic, and sedative characteristics of dexmedetomidine compared with
Publikováno v:
Anesthesiology. 109:213-224
Background Propofol may produce amnesia by affecting encoding. The hypothesis that propofol weakens encoding was tested by measuring regional cerebral blood flow during verbal encoding. Methods Seventeen volunteer participants (12 men; aged 30.4 +/-
Behavior of Entropy/Complexity Measures of the Electroencephalogram during Propofol-induced Sedation
Publikováno v:
Anesthesiology. 106:696-706
Background Several new measures based on the regularity of the electroencephalogram signal for the assessment of depth of anesthesia/sedation have been proposed recently. In this study we analyze the influence of remifentanil and electroencephalogram
Publikováno v:
Anesthesiology. 104:1170-1175
Background Loss of consciousness (LOC) and immobility to surgical incision seem to be mediated at different levels of the central nervous system. Pharmacologic studies of hypnotic agents have previously focused on combinations of either volatile or i
Autor:
Suzanne Karan, Denham S. Ward, Linda Palmer, Anna Varlese, Peter L. Bailey, J. Russell Norton, William A. Voter, Ori Rackovsky
Publikováno v:
Anesthesiology. 104:1155-1164
Background Upper airway obstruction (UAO) during sedation can often cause clinically significant adverse events. Direct comparison of different drugs' propensities for UAO may improve selection of appropriate sedating agents. The authors used the app