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Publikováno v:
Anesthesiology. 124:598-607
BackgroundSedation is commonly used in neurosurgical patients but has been reported to produce transient focal neurologic dysfunction. The authors hypothesized that in patients with frontal–parietal–temporal brain tumors, focal neurologic deficit
Autor:
Jeremy M. Kahn, Andrew A. Kramer, Robert N. Sladen, Gordon D. Rubenfeld, Hannah Wunsch, Gebhard Wagener, Guohua Li
Publikováno v:
Anesthesiology. 113:386-394
Background Dexmedetomidine is a novel sedative agent that causes anxiolysis without respiratory depression in critically ill patients. We sought to examine patient and hospital variation in dexmedetomidine use and adoption patterns of dexmedetomidine
Publikováno v:
Anesthesiology. 108:122-129
Background The significant postnatal maturation of gamma-aminobutyric acid signaling in the developing brain is likely to have important implications for infant pain processing. Gamma-aminobutyric acid receptor activation evokes analgesia and sedatio
Autor:
Anna I. Hårdemark Cedborg, Richard Kuylenstierna, Olle Ekberg, Katarina Bodén, Eva Sundman, Hanne Witt Hedström, Lars Eriksson
Publikováno v:
Anesthesiology. 122(6)
Background: Drugs used for sedation in anesthesia and intensive care may cause pharyngeal dysfunction and increased risk for aspiration. In this study, the authors investigate the impact of sedative doses of morphine and midazolam on pharyngeal funct
Autor:
Suzanne Karan, Denham S. Ward, Linda Palmer, Anna Varlese, Peter L. Bailey, J. Russell Norton, William A. Voter, Ori Rackovsky
Publikováno v:
Anesthesiology. 104:1155-1164
Background Upper airway obstruction (UAO) during sedation can often cause clinically significant adverse events. Direct comparison of different drugs' propensities for UAO may improve selection of appropriate sedating agents. The authors used the app
Publikováno v:
Anesthesiology. 97:447-453
Background The effects of propofol on memory for aversive information are not well determined. The authors evaluated the effects of a minimal nonsedative dose of propofol or midazolam on memory in rats, using an apparatus composed of two compartments
Publikováno v:
Anesthesiology. 96:196-201
Background The goal of the current study was to evaluate the economic impact of propofol as compared with midazolam for sedating patients in the intensive care unit (ICU). Methods A randomized, unblinded, multicenter pharmacoeconomic trial captured h
Publikováno v:
Anesthesiology. 95:896-907
Background Sedative-hypnotic drugs not only increase sedation, but also impair memory as serum concentration increases. These drugs also produce profound changes in the auditory event-related potential (ERP). The ability of various ERP components to
Publikováno v:
Anesthesiology. 93:1217-1224
Background Results of previous studies of rectal ketamine as a pediatric premedication are clouded because of lack of dose-response relation, inappropriate time of assessing sedative effects, and previous administration or coadministration of benzodi
Autor:
Dawn M. Krivutza, Maura B. Hofstadter, Gerianne M. Alexander, Shu-Ming Wang, J. Steven Reznick, Linda C. Mayes, Zeev N. Kain
Publikováno v:
Anesthesiology. 93:676-684
Background The minimum time interval between administration of oral midazolam and separation of children from their parents that ensures good anterograde amnesia has not been previously determined. This is of particular importance in a busy operating