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Autor:
Christopher M. Peters, Douglas G. Ririe, James C. Eisenach, Timothy T. Houle, Carol A. Aschenbrenner
Publikováno v:
Anesthesiology. 120:976-986
Background: Long-lasting, sensory-specific peripheral nerve blockade would advance perioperative analgesia. Perineural injection of a combination of transient receptor potential vanilloid 1 channel agonists and lidocaine or its hydrophilic derivative
Publikováno v:
Anesthesiology. 124(5)
Background Tissue injury enhances pain sensitivity both at the site of tissue damage and in surrounding uninjured skin (secondary hyperalgesia). Secondary hyperalgesia encompasses several pain symptoms including pain to innocuous punctate stimuli or
Publikováno v:
Anesthesiology. 114:135-149
Background Postoperative pain can occur despite nerve blocks during the surgical period. Here we tested Xybrex (Orthocon, Inc., Irvington, NY), a slow-release formulation of lidocaine that blocks rat sciatic nerve for 1-2 days, for its ability to sup
Publikováno v:
Anesthesiology. 102:1226-1234
Background Epidural alpha2-adrenergic agonists produce analgesic effects in children and adults, but efficacy and safety have not been established in neonates and infants. The aim of this study was to determine the effect of epidural dexmedetomidine
Publikováno v:
Anesthesiology. 102:421-428
Background Although opioids are unsurpassed analgesics, experimental and clinical studies suggest that opioids activate N-methyl-d-aspartate pronociceptive systems leading to pain hypersensitivity and short-term tolerance. Because it is difficult in
Publikováno v:
Anesthesiology. 89:190-201
Background The current study aimed to assess whether local administration of morphine could block the development of hyperalgesia and allodynia in a rat model of osteotomy or bone damage. Methods Withdrawal responses to mechanical and thermal stimuli
Publikováno v:
Anesthesiology. 85:808-816
Background Three types of opioid receptors, mu, delta, and kappa, are present in the periphery and in the central nervous system. In contrast to the effects in the central nervous system, the antinociceptive action of opioids in the periphery is not
Publikováno v:
Anesthesiology. 84:1129-1137
Background Recent evidence has suggested that the timing of administration of analgesic drugs could influence their efficacy by reducing the sensitization of the nervous system induced by the nociceptive inputs, but this concept of preemptive analges
Autor:
Joseph R. Holtman, Elzbieta P. Wala
Publikováno v:
Anesthesiology. 106(3)
Background Recently, it has been appreciated that in addition to their antinociceptive properties, opioid analgesics also can enhance pain sensitivity (opioid-induced hyperalgesia [OIH]). OIH may enhance preexisting pain and contribute to dose escala
Autor:
Frank Porreca, Mohab M. Ibrahim, Todd W. Vanderah, Michael H. Ossipov, T. Philip Malan, Josephine Lai, Aline Quartilho, Heriberto P. Mata
Publikováno v:
Anesthesiology. 100(6)
Background Administration of opioid receptor agonists is followed by paradoxical sensory hypersensitivity. This hypersensitivity has been suggested to contribute to the antinociceptive tolerance observed with opioids. The authors hypothesized that al