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Publikováno v:
Anesthesiology. 132:1138-1150
BackgroundAs severe acute hypoxemia produces a rapid inhibition of the respiratory neuronal activity through a nonopioid mechanism, we have investigated in adult rats the effects of hypoxemia after fentanyl overdose-induced apnea on (1) autoresuscita
Publikováno v:
Anesthesiology. 132:1197-1211
Background Opioids can induce significant respiratory depression when administered as analgesics for the treatment of acute, postoperative, and chronic pain. There are currently no pharmacologic means of reversing opioid-induced respiratory depressio
Autor:
Karen L. Syrjala, Megan C. Kelton-Rehkopf, Danny D. Shen, Michael J. Loughren, Evan D. Kharasch
Publikováno v:
Anesthesiology. 132:491-503
BackgroundPatients often use complementary and alternative herbal medicines, hence, potential exists for adverse herb–drug interactions. Fentanyl is metabolized by hepatic CYP3A4 and considered transported by blood–brain barrier P-glycoprotein. B
Publikováno v:
Anesthesiology. 130:1017-1031
Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Opioid analgesics are widely used for treatment of acute, postoperative, and chronic pain. However, activation of opioid receptors can resu
Autor:
Gregory J. Trenk, Glenn S. Murphy, Jessica Benson, Mark A. Deshur, Joseph W. Szokol, Michael J. Avram, Kevin J. Teister, Steven Greenberg, Torin D. Shear, Sara Bilimoria, David M. Dickerson, Colleen E. Maher
Publikováno v:
Anesthesiology. 132(2)
Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Methadone is a long-acting opioid that has been reported to reduce postoperative pain scores and analgesic requirements and may attenuate d
Autor:
Paul C. Fitzgerald, Wilmer F. Davila, Suman Rao, Paloma Toledo, Elizabeth M. S. Lange, Robert J. McCarthy, Cynthia A. Wong
Publikováno v:
Anesthesiology. 128:745-753
Background Programmed intermittent boluses of local anesthetic have been shown to be superior to continuous infusions for maintenance of labor analgesia. High-rate epidural boluses increase delivery pressure at the catheter orifice and may improve dr
Publikováno v:
Anesthesiology. 127:614-624
Background Breastfeeding is an important public health concern. High cumulative doses of epidural fentanyl administered for labor analgesia have been reported to be associated with early termination of breastfeeding. We tested the hypothesis that bre
Autor:
Robert J. McCarthy, Nicole Higgins, Paloma Toledo, Feyce M. Peralta, Laurie A. Chalifoux, Jeanette R. Bauchat, Jason Farrer, John T. Sullivan, Susan E. Gerber
Publikováno v:
Anesthesiology. 127:625-632
Background Breech presentation is a leading cause of cesarean delivery. The use of neuraxial anesthesia increases the success rate of external cephalic version procedures for breech presentation and reduces cesarean delivery rates for fetal malpresen
Autor:
Béla Fülesdi, Szabolcs Lengyel, Edömér Tassonyi, László Asztalos, András Gajdos, Adrienn Pongrácz, Zoltán Szabó-Maák, Réka Nemes
Publikováno v:
Anesthesiology. 127:441-449
Background Rocuronium-induced neuromuscular block that spontaneously recovered to a train-of-four count of four can be reversed with sugammadex 0.5 or 1.0 mg/kg. We investigated whether these doses of sugammadex can also reverse vecuronium at a simil
Autor:
Kenneth E. Nelson, James C. Eisenach, Peter H. Pan, Jessica L. Booth, Lynnette Harris, Vernon H. Ross
Publikováno v:
Anesthesiology. 127:50-57
Background The addition of opioids to epidural local anesthetic reduces local anesthetic consumption by 20% but at the expense of side effects and time spent for regulatory compliance paperwork. Epidural neostigmine also reduces local anesthetic use.