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Publikováno v:
Anesthesiology. 126:708-715
Background Cebranopadol is a first-in-class analgesic with agonist activity at classic opioid peptide receptors and the nociceptin/orphanin FQ peptide receptor. The authors compared the antinociceptive and respiratory depressant effects of cebranopad
Publikováno v:
Anesthesiology. 125:1229-1241
A 77 year-old male is admitted to the hospital after sustaining a hip fracture. He has a past medical history of chronic obstructive pulmonary disease, hypertension, hyperlipidemia, chronic back pain, and hearing loss. Prior to surgery he receives mi
Autor:
Kanwaljeet J. S. Anand
Publikováno v:
Anesthesiology. 131(2)
Randomised Trial of Fentanyl Anesthesia in Preterm Babies Undergoing Surgery: Effects on the Stress Response. By Anand KJ, Sippell WG, and Aynsley-Green A. Lancet 1987; 1:243–8. Reprinted with permission.In a randomised controlled trial, preterm ba
Publikováno v:
Anesthesiology. 124:598-607
BackgroundSedation is commonly used in neurosurgical patients but has been reported to produce transient focal neurologic dysfunction. The authors hypothesized that in patients with frontal–parietal–temporal brain tumors, focal neurologic deficit
Autor:
Oliver Bandschapp, Joerg Filitz, Wilhelm Ruppen, Patrick C. Dolder, Eckhard Mauermann, Katharina Rentsch
Publikováno v:
Anesthesiology. 124:453-463
BackgroundAlthough opioids in general and remifentanil in particular have been shown to induce hyperalgesia, data regarding fentanyl are scarce. Thus, the authors investigated the effect of fentanyl dosing on pain perception and central sensitization
Publikováno v:
Anesthesiology. 122:1280-1287
Background:To compare surgical pleth index (SPI)-guided analgesia with conventional analgesia by evaluating intraoperative analgesic requirements, postoperative pain, and emergence agitation in children.Methods:This study was designed as a parallel,
Autor:
Dhanesh K. Gupta, Shivani A. Patel, Jesse H. Marymont, Joseph W. Szokol, Torin D. Shear, Michael J. Avram, Steven Greenberg, Glenn S. Murphy, Kruti N. Parikh
Publikováno v:
Anesthesiology. 122:1112-1122
Background: The intensity of pain after cardiac surgery is often underestimated, and inadequate pain control may be associated with poorer quality of recovery. The aim of this investigation was to examine the effect of intraoperative methadone on pos
Autor:
Ingebjørg Seljeflot, Espen Lindholm, Erlend Aune, Jan Erik Otterstad, Camilla B. Norén, Thomas Hayes, Knut Arvid Kirkebøen
Publikováno v:
Anesthesiology. 119:802-812
Background: On the basis of data indicating that volatile anesthetics induce cardioprotection in cardiac surgery, current guidelines recommend volatile anesthetics for maintenance of general anesthesia during noncardiac surgery in hemodynamic stable
Autor:
Meike Neukirchen, Geert Jan Groeneveld, Albert Dahan, Elise Sarton, Leon Aarts, Merel Boom, Justin L. Hay, René Fussen, Erik Olofsen
Publikováno v:
Anesthesiology. 119:663-674
Introduction: Integrating opioid risk and benefit into a single function may give a useful single measure of the opioid’s positive and negative effects. An explorative study on the effects of fentanyl on antinociception and respiratory depression w
Autor:
Johannes H. Proost, Bjorn Heyse, Hugo Vereecke, Martin Luginbühl, Takasumi Katoh, Michel Struys, Douglas J. Eleveld
Publikováno v:
Anesthesiology. 118:894-902
Background: The interaction of sevoflurane and opioids can be described by response surface modeling using the hierarchical model. We expanded this for combined administration of sevoflurane, opioids, and 66 vol.% nitrous oxide (N2O), using historica