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Autor:
Katrin Kistner, Carla Nau, Peter W. Reeh, Andreas Leffler, Wolfgang Koppert, Florian Niedermirtl, Georg Frank
Publikováno v:
Anesthesiology. 116:1335-1346
Background Opioids induce analgesia mainly by inhibiting synaptic transmission via G protein-coupled opioid receptors. In addition to analgesia, buprenorphine induces a pronounced antihyperalgesia and is an effective adjuvant to local anesthetics. Th
Publikováno v:
Anesthesiology. 111:1334-1345
Background: Remifentanil anesthesia enhances postopera- tive pain in animals and humans. The authors evaluated the impact of the dose (gkg 1 � min 1 ) and duration of remifen- tanil infusion, and the effects of a second surgery on postoper- ative p
Autor:
Wolfgang Ummenhofer, Christopher M. Bernards, Emily S. Sterling, Jason E. Adkins, Brian Phillips, Danny D. Shen, Linda J. Risler
Publikováno v:
Anesthesiology. 99:466-475
Background The ability of epinephrine to improve the efficacy of epidurally administered drugs is assumed to result from local vasoconstriction and a consequent decrease in drug clearance. However, because drug concentration in the epidural space has
Autor:
Wolfgang Ummenhofer, Christopher M. Bernards, Brian Phillips, Jason E. Adkins, Linda J. Risler, Danny D. Shen, Emily S. Sterling
Publikováno v:
Anesthesiology. 99:455-465
Background The pharmacokinetics of epidurally administered drugs has been the subject of many studies, yet drug concentration in the epidural space has never been measured. This study was undertaken to characterize the epidural, cerebrospinal fluid,
Publikováno v:
Anesthesiology. 92:739-753
Background Despite widespread use, little is known about the comparative pharmacokinetics of intrathecally administered opioids. The present study was designed to characterize the rate and extent of opioid distribution within cerebrospinal fluid, spi
Autor:
Jackie Wiley, J. Elaine Sidawi, Shiv K. Sharma, Kenneth J. Leveno, Michael J. Lucas, David R. Gambling, Susan M. Ramin
Publikováno v:
Anesthesiology. 89:1336-1344
Background Combined spinal-epidural (CSE) analgesia produces rapid-onset pain relief and allows ambulation in early labor. Epidural local anesthetics may contribute to an increase in operative deliveries by decreasing perineal sensation and causing m
Autor:
Evan D. Kharasch
Publikováno v:
Anesthesiology. 122:969-970
In fashion, the most variable style element is the hemline - ranging from ultra-short (hip-high miniskirt) to ultra-long (floor-length).* In anesthesiology, there has been similar fashion in opioid use, with the most variable element being the elimin
Publikováno v:
Anesthesiology. 87:127-134
Background One measure of an opioid's efficacy is its ability to retain its analgesic effect as the intensity of a noxious stimulus is increased. A few studies have assessed the ability of either spinal or systemic opioids to produce analgesia using
Autor:
Valerie Billard, Charles F. Minto, Thomas W. Schnider, Jaap W. Mandema, Talmage D. Egan, David J. Hermann, John F. Hoke, Steven L. Shafer, Pedro L. Gambús, Harry J. M. Lemmens, Katherine H. P. Moore, Keith T. Muir, Elizabeth J. Youngs
Publikováno v:
Anesthesiology. 86:10-23
Background Previous studies have reported conflicting results concerning the influence of age and gender on the pharmacokinetics and pharmacodynamics of fentanyl, alfentanil, and sufentanil. The aim of this study was to determine the influence of age
Publikováno v:
Anesthesiology. 83:300-308
Background This randomized double-blind investigation was designed to study the placental transfer and neonatal effects of epidural sufentanil and fentanyl infused with bupivacaine for labor analgesia. Methods Healthy parturient women (n = 36) receiv