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Publikováno v:
Anesthesiology. 74:34-42
The authors compared the pharmacodynamics of sufentanil with those of fentanyl using the electroencephalogram (EEG) as a measure of opioid drug effect. Sixteen patients were given a rapid infusion of sufentanil (18.75 micrograms/min) during EEG recor
Publikováno v:
Anesthesiology. 2000
Background The use of intrathecal opioids for labor analgesia continues to gain popularity, but there are limited data to guide this use. Previously, the authors established the ED50 for 60 min of labor analgesia from intrathecal sufentanil using an
Publikováno v:
Anesthesiology. 75(5)
It was suggested that for a given analgesic effect, more potent opioids may produce smaller degrees of tolerance than those with lower analgesic potency. The use of opioids with high analgesic potency to reduce the rate of tolerance development would
Autor:
Steven L. Shafer, John R. Varvel
Publikováno v:
Anesthesiology. 74(1)
Fentanyl, alfentanil, and sufentanil have important pharmacokinetic and pharmacodynamic differences. Selecting one of these opioid analgesics as an adjunct to general anesthesia requires appreciation of the relationship between the pharmacokinetic an
Autor:
Richard Ward, T. Bowdle
Publikováno v:
Anesthesiology. 70:26-30
The purpose of this study was to examine the dose versus EEG response relationship, the speed of onset, and the thiopental requirement for induction of anesthesia with small doses of sufentanil and fentanyl. The power spectrum of the electroencephalo
Publikováno v:
Anesthesiology. 66:186-194
The experiments examined the characteristics of analgesia produced by different doses of morphine, meperidine (pethidine), fentanyl, and sufentanil after epidural and subcutaneous injection in rats. The specificity of the analgesia was also determine
Autor:
James Mckenna, Marc Goldberg
Publikováno v:
Anesthesiology. 64:665-666