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Autor:
Karen L. Syrjala, Megan C. Kelton-Rehkopf, Danny D. Shen, Michael J. Loughren, Evan D. Kharasch
Publikováno v:
Anesthesiology. 132:491-503
BackgroundPatients often use complementary and alternative herbal medicines, hence, potential exists for adverse herb–drug interactions. Fentanyl is metabolized by hepatic CYP3A4 and considered transported by blood–brain barrier P-glycoprotein. B
Autor:
Evan D. Kharasch, Carl E. Rosow
Publikováno v:
Anesthesiology. 119:504-506
Integrating opioid risk and benefit into a single function may give a useful single measure of the opioid's positive and negative effects. An explorative study on the effects of fentanyl on antinociception and respiratory depression was performed to
Publikováno v:
Anesthesiology. 101:603-613
Background The currently available pharmacokinetic models for fentanyl were derived from normal weight patients and were not scaled to body weight. Their application to obese patients may cause overprediction of the plasma concentration of fentanyl.
Autor:
Wolfgang Ummenhofer, Christopher M. Bernards, Emily S. Sterling, Jason E. Adkins, Brian Phillips, Danny D. Shen, Linda J. Risler
Publikováno v:
Anesthesiology. 99:466-475
Background The ability of epinephrine to improve the efficacy of epidurally administered drugs is assumed to result from local vasoconstriction and a consequent decrease in drug clearance. However, because drug concentration in the epidural space has
Autor:
Wolfgang Ummenhofer, Christopher M. Bernards, Brian Phillips, Jason E. Adkins, Linda J. Risler, Danny D. Shen, Emily S. Sterling
Publikováno v:
Anesthesiology. 99:455-465
Background The pharmacokinetics of epidurally administered drugs has been the subject of many studies, yet drug concentration in the epidural space has never been measured. This study was undertaken to characterize the epidural, cerebrospinal fluid,
Publikováno v:
Anesthesiology. 98:853-861
Background Parecoxib is a parenteral cyclooxygenase-2 (COX-2) inhibitor intended for perioperative analgesia. It is an inactive prodrug hydrolyzed in vivo to the active inhibitor valdecoxib, a substrate for hepatic cytochrome P450 3A4 (CYP3A4); hence
Autor:
Scott McJames, Ken B. Johnson, Talmage D. Egan, Steven E. Kern, Elizabeth A. Hamber, Katelijne M. Kohnstamm
Publikováno v:
Anesthesiology. 94:322-332
Background Hemorrhagic shock is known to alter significantly the pharmacokinetics of fentanyl, an opioid that requires delivery to the liver for metabolism. The authors hypothesized that the pharmacokinetics and pharmacodynamics of remifentanil, an e
Autor:
Takahisa Goto, Katsuo Terui, Hayato Saito, Yoshiki Ishiguro, Yoshinori Nakata, Yoshihiko Tsuruta, Shigeho Morita, Yoshinari Niimi, Hiromasa Kawakami
Publikováno v:
Anesthesiology. 92:1043-1048
Background Although anesthesia with xenon has been supplemented with fentanyl, its requirement has not been established. This study was conducted to determine the plasma concentrations of fentanyl necessary to suppress somatic and hemodynamic respons
Autor:
Jur Kievit, Talmage D. Egan, James B. Streisand, Michael A. Ashburn, Nathan L. Pace, Amarnath Sharma
Publikováno v:
Anesthesiology. 92:665-673
Background Oral transmucosal fentanyl citrate (OTFC) is a solid form of fentanyl that delivers the drug through the oral mucosa. The clinical utility of multiple doses of OTFC in the treatment of "breakthrough" cancer pain is under evaluation. The ai
Publikováno v:
Anesthesiology. 91:156-166
Background It is common clinical practice to administer reduced doses of opioid to patients suffering from hemorrhagic shock to minimize adverse hemodynamic consequences and to prevent prolonged opioid effect However, the scientific foundation suppor