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Autor:
James M. Bailey
Publikováno v:
Anesthesiology. 78:116-123
BACKGROUND There is increasing interest among anesthesiologists in the use of continuous infusion of intravenous drugs. The therapeutic effect of most drugs is a function of the concentration at the site of drug effect, which in turn is determined by
Publikováno v:
Anesthesiology. 75:420-425
Epidural clonidine produces postoperative analgesia in patients and potentiates opioid analgesia in animals. The aim of the current study was to assess the effect of epidural clonidine on the plasma concentrations and analgesic effect of fentanyl aft
Autor:
Michael A. Ashburn, James B. Streisand, Brian Hague, Stephen D. Tarver, John R. Varvel, Donald R. Stanski, Leon Le Maire, Theodore H. Stanley
Publikováno v:
Anesthesiology. 75:223-229
Oral transmucosal fentanyl citrate (OTFC) is a novel, noninvasive dosage form of fentanyl used to provide children and adults with sedation, anxiolysis, and analgesia. In order to determine the bioavailability and absorption of fentanyl from OTFC, 12
Autor:
Nobuhiko Yasuda, Richard B. Welskopf, Stephen H. Lockhart, Edmond I. Eger, Brynte H. Johnson, Argyro Fassoulaki, Beth Freire
Publikováno v:
Anesthesiology. 74:479-483
We studied the percutaneous losses of the new inhaled anesthetic, desflurane (I-653), and of isoflurane and halothane during anesthetic administration and elimination in seven healthy male volunteers. Anesthesia was induced and maintained with midazo
Publikováno v:
Anesthesiology. 74:264-269
Eight patients (7 men and 1 woman, 45-68 yr old) scheduled to undergo thoracotomy were given, preoperatively, 15 micrograms sufentanil in the lumbar intrathecal space for a study of cerebrospinal fluid (CSF) and plasma kinetics of sufentanil. Multipl
Autor:
L. R. Smith, Peter S. A. Glass, Stephen A. Bai, Joseph G. Reves, Brian Ginsberg, T J Quill, James R. Jacobs
Publikováno v:
Anesthesiology. 73:1082-1090
Computer-assisted continuous infusion (CACI) is a pharmacokinetic model-driven infusion device that enables physicians to administer intravenous (iv) drugs in a quantitative fashion, specifying a theoretical blood or plasma concentration. This study
Publikováno v:
Anesthesiology. 72:981-986
The authors conducted a randomized double-blind controlled study comparing groups of patients receiving iv or epidural fentanyl infusions to determine whether, at comparable levels of analgesia, 1) the severity of side effects was different; and 2) p
Publikováno v:
Anesthesiology. 72:865-873
The steady-state tissue/blood partition coefficients of fentanyl and alfentanil were determined in 13 organs and tissues in the rat. A 6-h infusion of both drugs was used in order to achieve steady-state. Blood and tissue concentrations of drugs were
Publikováno v:
Anesthesiology. 72:650-658
The authors have used computer simulation to examine the time course of the plasma concentration, estimated effect site concentration, and the intensity of the central nervous system (CNS) effect of fentanyl and alfentanil. The simulations were perfo
Publikováno v:
Anesthesiology. 101(3)
Background Cancer pain is primarily a problem of older persons. Oral transmucosal fentanyl citrate (OTF) was developed to provide rapid analgesia and is the first drug specifically approved for treating breakthrough cancer pain. Fentanyl in OTF is ab