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Publikováno v:
Anesthesiology. 132:1138-1150
BackgroundAs severe acute hypoxemia produces a rapid inhibition of the respiratory neuronal activity through a nonopioid mechanism, we have investigated in adult rats the effects of hypoxemia after fentanyl overdose-induced apnea on (1) autoresuscita
Publikováno v:
Anesthesiology. 132:1197-1211
Background Opioids can induce significant respiratory depression when administered as analgesics for the treatment of acute, postoperative, and chronic pain. There are currently no pharmacologic means of reversing opioid-induced respiratory depressio
Publikováno v:
Anesthesiology. 130:1017-1031
Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Opioid analgesics are widely used for treatment of acute, postoperative, and chronic pain. However, activation of opioid receptors can resu
Autor:
Gregory J. Trenk, Glenn S. Murphy, Jessica Benson, Mark A. Deshur, Joseph W. Szokol, Michael J. Avram, Kevin J. Teister, Steven Greenberg, Torin D. Shear, Sara Bilimoria, David M. Dickerson, Colleen E. Maher
Publikováno v:
Anesthesiology. 132(2)
Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Methadone is a long-acting opioid that has been reported to reduce postoperative pain scores and analgesic requirements and may attenuate d
Autor:
Michael J, Loughren, Evan D, Kharasch, Megan C, Kelton-Rehkopf, Karen L, Syrjala, Danny D, Shen
Publikováno v:
Anesthesiology
BACKGROUND: Patients often use complementary and alternative herbal medicines; hence potential exists for adverse herb-drug interactions. Fentanyl is metabolized by hepatic CYP3A4 and considered transported by blood-brain barrier P-glycoprotein. Both
Publikováno v:
Anesthesiology. 126:708-715
Background Cebranopadol is a first-in-class analgesic with agonist activity at classic opioid peptide receptors and the nociceptin/orphanin FQ peptide receptor. The authors compared the antinociceptive and respiratory depressant effects of cebranopad
Publikováno v:
Anesthesiology. 124:598-607
BackgroundSedation is commonly used in neurosurgical patients but has been reported to produce transient focal neurologic dysfunction. The authors hypothesized that in patients with frontal–parietal–temporal brain tumors, focal neurologic deficit
Publikováno v:
Anesthesiology. 120:1292-1297
Publikováno v:
Anesthesiology. 125(1)
The nociception level (NoL) index is an index of nociception based on nonlinear combination of heart rate, heart rate variability, photoplethysmograph wave amplitude, skin conductance, skin conductance fluctuations, and their time derivatives. The au
Autor:
Eckhard, Mauermann, Joerg, Filitz, Patrick, Dolder, Katharina M, Rentsch, Oliver, Bandschapp, Wilhelm, Ruppen
Publikováno v:
Anesthesiology. 124(2)
Although opioids in general and remifentanil in particular have been shown to induce hyperalgesia, data regarding fentanyl are scarce. Thus, the authors investigated the effect of fentanyl dosing on pain perception and central sensitization in health