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Publikováno v:
Anesthesiology. 87:127-134
Background One measure of an opioid's efficacy is its ability to retain its analgesic effect as the intensity of a noxious stimulus is increased. A few studies have assessed the ability of either spinal or systemic opioids to produce analgesia using
Publikováno v:
Anesthesiology. 83:300-308
Background This randomized double-blind investigation was designed to study the placental transfer and neonatal effects of epidural sufentanil and fentanyl infused with bupivacaine for labor analgesia. Methods Healthy parturient women (n = 36) receiv
Autor:
Marc De Kock, Theo F. Meert
Publikováno v:
Anesthesiology. 81:677-688
Background: Data on the analgesic properties of alpha(2) agonists and their interactions with opioids are conflicting. Experiments were conducted in rats to evaluate whether various available alpha(2) agonists can potentiate the analgesic properties
Autor:
John C. Peterson, Peter L. Bailey, R. J. Sperry, Mark V. Reichman, Peggy B. Petersen, Nathan L. Pace
Publikováno v:
Anesthesiology. 77:416-420
Although opioids frequently are administered to patients with severe head trauma, the effects of such drugs on intracranial pressure are controversial. Nine patients with severe head trauma were studied for the effects of fentanyl and sufentanil on i
Publikováno v:
Anesthesiology. 76:209-215
Nasal administration of sufentanil or midazolam is effective for preinduction of pediatric patients, but there are no data on which to base a choice between them. This blinded randomized study compares behavioral and physiologic responses to sedation
Publikováno v:
Anesthesiology. 74:264-269
Eight patients (7 men and 1 woman, 45-68 yr old) scheduled to undergo thoracotomy were given, preoperatively, 15 micrograms sufentanil in the lumbar intrathecal space for a study of cerebrospinal fluid (CSF) and plasma kinetics of sufentanil. Multipl
Autor:
Tony L. Yaksh, Maurice Sosnowski
Publikováno v:
Anesthesiology. 73:1141-1147
By means of a subcutaneously implanted osmotic pump, groups of rats received a constant-rate (1 microliter/h), 7-day intrathecal infusion of saline or one of two mu opioid agonists: sufentanil (0.6 nmol/h) or morphine (20 nmol/h). These concentration
Publikováno v:
Anesthesiology. 99(1)
Background: Despite decades of use, controversy remains regarding the extent and time course of cephalad spread of opioids in cerebrospinal fluid (CSF) after intrathecal injection. The purpose of this study was to examine differences between two ofte
Publikováno v:
Anesthesiology. 89(4)
Background Concentration-response relationships for sufentanil and fentanyl are undefined in patients undergoing coronary artery bypass grafting. Methods Separate studies of sufentanil and fentanyl were performed in lorazepam-premedicated patients un
Autor:
Barbara A. Coda, Mary Cleveland Brown, Danny D. Shen, R. Schaffer, Gary W. Donaldson, Robert Jacobson, Barbara Hautman
Publikováno v:
Anesthesiology. 81(5)
Background Despite a large number of clinical investigations in postoperative patients, the pharmacology of epidural fentanyl, alfentanil, and sufentanil has not been well characterized in a human laboratory setting. In this double-blind, placebo-con