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Publikováno v:
Anesthesiology. 83:277-284
Background Pulmonary administration of fentanyl solution can provide satisfactory but brief postoperative pain relief. Liposomes are microscopic phospholipid vesicles that can entrap drug molecules. Liposomal delivery of fentanyl has the potential to
Publikováno v:
Anesthesiology. 78:1157-1165
Background:Many drugs are removed by the lung. The pulmonary uptake of one drug can be inhibited when a second, highly accumulated drug is administered parenterally or as a chronic oral treatment. The effect of inhalational anesthetics on pulmonary d
Publikováno v:
Anesthesiology. 101(3)
Background Cancer pain is primarily a problem of older persons. Oral transmucosal fentanyl citrate (OTF) was developed to provide rapid analgesia and is the first drug specifically approved for treating breakthrough cancer pain. Fentanyl in OTF is ab
Autor:
Steven L. Shafer, Elizabeth J. Youngs
Publikováno v:
Anesthesiology. 81(4)
Several recent studies have suggested that the terminal half-lives of many drugs do not predict the rate of washout of drug after the relatively short durations of infusions used in anesthesia. Many anesthetic drugs fit a three-compartment mamillary
Autor:
Suneel K. Gupta, Kathleen M. Foley, Charles E. Inturrisi, Mary Layman, Russell K. Portenoy, Mary Southam, Jeanne Lapin
Publikováno v:
Anesthesiology. 78(1)
The transdermal therapeutic system (fentanyl), or TTS(fentanyl), continuously delivers fentanyl for up to 72 h. The transdermal therapeutic system (fentanyl)-100 delivers approximately 100 micrograms/h. The repeated dose pharmacokinetics of this drug
Autor:
Barbara E. Waud, Douglas R. Waud
Publikováno v:
Anesthesiology. 65(4)