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Publikováno v:
Anesthesiology. 134:617-625
Background The median effective dose of ropivacaine required for producing an effective costoclavicular block has not yet been determined. The authors conducted this dose-finding study with the objective of determining the median effective dose of 0.
Publikováno v:
Anesthesiology. 125(3)
Rapid intravenous administration of lipid emulsion has become the standard treatment of severe local anesthetic systemic toxicity. This experiment in volunteers aimed at determining the effect of Intralipid® administration on the time to neurologic
Publikováno v:
Anesthesiology. 113:445-453
Background The potencies of bupivacaine and ropivacaine have been compared using up-and-down methodology, but their complete dose-response curves have not been compared. The authors performed a random allocation-graded dose-response study of epidural
Autor:
Lennart Jeppsson, Jan Sjövall, Gunilla Huledal, Alain Borgeat, Georgios Ekatodramis, Lars Westman
Publikováno v:
Anesthesiology. 98:143-150
Background In this open, randomized study, the pharmacokinetics, clinical efficacy, and safety of a 48-h continuous interscalene infusion of 2 mg/ml ropivacaine for postoperative pain relief were investigated in patients undergoing open major shoulde
Autor:
Kylie A. Wilson, Leigh A. Ladd, Laurence E. Mather, John L. Plummer, Dennis Hsu-Tung Chang, Susan E. Copeland
Publikováno v:
Anesthesiology. 97:418-428
Background Previous preclinical safety studies in ewes have found intravenous levobupivacaine and ropivacaine to be less potent toward causing central nervous system (CNS) and cardiac toxicity than bupivacaine. Analogous cardiotoxicity has been demon
Autor:
Jean-Marc Malinovsky, Pascal Le Corre, Florence Charles, Yann Péréon, Michel Pinaud, Dan Benhamou, Marielle Baudrimont
Publikováno v:
Anesthesiology. 97:429-435
Background Ropivacaine is available for spinal or intrathecal use in humans, although data on neurotoxicity after spinal injection are not yet available. The authors experimentally determined the relationship between doses of intrathecal ropivacaine
Publikováno v:
Anesthesiology. 96:1427-1434
Background Ropivacaine is believed to have a lower incidence of clinical cardiac side effects than bupivacaine. The aim of this study was to compare the direct cardiac effects of the optically pure S(-)-ropivacaine isomer and its nonclinically used R
Publikováno v:
Anesthesiology. 88:1340-1349
Background High lipophilic local anesthetics interfere with mitochondrial energy metabolism. These metabolic effects could in part explain some of the toxic effects of local anesthetics, such as bupivacaine-induced myocardial depression. The aim of t
Publikováno v:
Anesthesiology. 112(5)
Background Thoracic epidural anesthesia can contribute to facilitate the fast-track approach in lung surgery. However, data regarding the effects of thoracic epidural anesthesia on oxygenation during one-lung ventilation (OLV) are scarce and contradi
Publikováno v:
Anesthesiology. 111(5)
Background The current study was designed to test the hypothesis that dexmedetomidine added to ropivacaine would increase the duration of antinociception to a thermal stimulus in a dose-dependent fashion in a rat model of sciatic nerve blockade. Meth