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Publikováno v:
Anesthesiology. 114:150-161
Background Sensory neuron opioid receptors are targets for spinal, epidural, and peripheral opioid application. Although local nerve growth factor (NGF) has been identified as a mediator of sensory neuron μ-opioid receptor (MOR) up-regulation, the s
Autor:
Britta S. von Ungern-Sternberg, Damian M. Craig, Kathrin Keller, Franz J. Frei, Gary L. Rosner, Thomas O. Erb
Publikováno v:
Anesthesiology. 113:41-47
Background The modifying effects of fentanyl on protective airway reflexes have not been characterized in children. The aim of this study was to assess the impact of increasing doses of fentanyl on laryngeal reflex responses in children anesthetized
Publikováno v:
Anesthesiology. 108:484-494
Background Opioid-induced hyperalgesia can develop rapidly after opioid exposure. Neuropathic pain and opioid-induced hyperalgesia share common pathophysiologic mechanisms. Gabapentin is effective for the management of neuropathic pain and may theref
Publikováno v:
Anesthesiology. 102:35-40
Background The authors examined the notion that a reduction in succinylcholine dose from 1 mg/kg to approximately 0.6 mg/kg would allow a faster recovery of spontaneous ventilation and reduction in the incidence of hemoglobin desaturation during the
Autor:
John J. Savarese, Brenna Stein, Patel Sanjay Shashikant, Cynthia A. Lien, Eleanor Bradley, Matthew R. Belmont, Joseph Tjan
Publikováno v:
Anesthesiology. 100:768-773
Background An ultrashort-acting nondepolarizing neuromuscular blocking agent that could be an alternative to succinylcholine has been the focus of a concerted effort in the field of muscle relaxants. GW280430A showed a promising pharmacodynamic profi
Publikováno v:
Anesthesiology. 89:894-906
Background Sufficient propofol or fentanyl doses necessary to prevent the response to skin incision do not necessarily attenuate hemodynamic responses during surgery. The goal of this study was to characterize the pharmacodynamic interaction between
Publikováno v:
Anesthesiology. 88:928-934
Background The propofol awakening concentration can vary. However, the effect site awakening propofol concentration will be a fixed value. The purpose of this study was to determine the awakening propofol concentrations obtained from infusion Schede
Publikováno v:
Anesthesiology. 87:127-134
Background One measure of an opioid's efficacy is its ability to retain its analgesic effect as the intensity of a noxious stimulus is increased. A few studies have assessed the ability of either spinal or systemic opioids to produce analgesia using
Publikováno v:
Anesthesiology. 82:996-1003
Background The release of excitatory neurotransmitters during ischemia is thought to contribute to ischemic neuronal injury. Volatile anesthetics have been shown to reduce excitatory neurotransmission in vitro, and it is conceivable that they reduce
Publikováno v:
Anesthesiology. 81:1371-1375
BACKGROUND Intrathecal opioids routinely are administered to surgical patients to provide prolonged postoperative analgesia. This study evaluated the dose-response effects of intrathecal fentanyl in an elderly patient population undergoing lower extr