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Publikováno v:
Anesthesiology. 132:1197-1211
Background Opioids can induce significant respiratory depression when administered as analgesics for the treatment of acute, postoperative, and chronic pain. There are currently no pharmacologic means of reversing opioid-induced respiratory depressio
Autor:
Kanwaljeet J. S. Anand
Publikováno v:
Anesthesiology. 131(2)
Randomised Trial of Fentanyl Anesthesia in Preterm Babies Undergoing Surgery: Effects on the Stress Response. By Anand KJ, Sippell WG, and Aynsley-Green A. Lancet 1987; 1:243–8. Reprinted with permission.In a randomised controlled trial, preterm ba
Autor:
Johannes H. Proost, Bjorn Heyse, Hugo Vereecke, Martin Luginbühl, Takasumi Katoh, Michel Struys, Douglas J. Eleveld
Publikováno v:
Anesthesiology. 118:894-902
Background: The interaction of sevoflurane and opioids can be described by response surface modeling using the hierarchical model. We expanded this for combined administration of sevoflurane, opioids, and 66 vol.% nitrous oxide (N2O), using historica
Autor:
Marc Lemaire, Jean Paul Laulin, Philippe Richebé, Guy Simonnet, Cyril Rivat, Cyril Creton, Pierre Maurette
Publikováno v:
Anesthesiology. 103:845-854
Background Although opioids are unsurpassed analgesics for surgery, they also induce an N-methyl-D-aspartate-dependent enhancement of postoperative hyperalgesia. Because nitrous oxide (N2O) has anti-N-methyl-D-aspartate properties, the purpose of thi
Autor:
John R. Lynch, David S. Warner, Maria Moldovan, Robert D. Pearlstein, Hazem Elsersy, Huaxin Sheng
Publikováno v:
Anesthesiology. 100:1160-1166
Background This study examined long-term outcome from severe forebrain ischemia in the rat, as a function of anesthetic given during the ischemic injury. Methods Rats were subjected to 10 min of near-complete forebrain ischemia while anesthetized wit
Autor:
Tetsuo Inoue, Tatsusuke Yoshikawa, Akira Ogura, Toshiya Shiga, Kazuyuki Imanaga, Zen’ichiro Wajima, Ryo Ogawa
Publikováno v:
Anesthesiology. 99:18-26
Background After induction of anesthesia, lung resistance increases. The authors hypothesized that prophylactic bronchodilator treatment with intravenous colforsin daropate, a water-soluble forskolin derivative, before tracheal intubation would resul
Publikováno v:
Anesthesiology. 82:996-1003
Background The release of excitatory neurotransmitters during ischemia is thought to contribute to ischemic neuronal injury. Volatile anesthetics have been shown to reduce excitatory neurotransmission in vitro, and it is conceivable that they reduce
Publikováno v:
Anesthesiology. 81:1264-1269
BACKGROUND It has been postulated that nitric oxide (NO) is a neurotransmitter involved in consciousness, analgesia, and anesthesia. Halothane has been shown to attenuate NO-mediated cyclic guanosine monophosphate accumulation in neurons, and a varie
Autor:
Elon H. Mehr, Karen S. Lindeman
Publikováno v:
Anesthesiology. 79:290-298
BACKGROUND General anesthetics modify airway responsiveness by several mechanisms, including direct effects on airway smooth muscle and reductions in neural reflex activity. Halothane has been shown to reduce responsiveness through both of these mech
Autor:
Ronald F. Albrecht, Eberhard Kochs, Dale A. Pelligrino, Jochem Schulte am Esch, Christian Werner, William E. Hoffman
Publikováno v:
Anesthesiology. 76:755-762
Central neuroexcitatory receptors (N-methyl-D-aspartate [NMDA], non-NMDA) may affect outcome from cerebral ischemia by altering sympathetic nervous system activity. We tested whether ketamine, an NMDA antagonist, and NBQX, a non-NMDA antagonist, impr