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Autor:
Gregory A. Chinn, Jennifer M. Sasaki Russell, Deenu Maharjan, Nicole A. Yabut, Jeffrey W. Sall
Publikováno v:
Anesthesiology
Background Cognitive deficits after perinatal anesthetic exposure are well established outcomes in animal models. This vulnerability is sex-dependent and associated with expression levels of the chloride transporters NKCC1 and KCC2. The hypothesis wa
Publikováno v:
Anesthesiology. 102:1158-1164
Background Similarities between naturally occurring sleep and general anesthesia suggest that the two states may interact physiologically. The authors have previously demonstrated that sleep deprivation potentiates anesthetic-induced loss of righting
Publikováno v:
Anesthesiology. 102:421-428
Background Although opioids are unsurpassed analgesics, experimental and clinical studies suggest that opioids activate N-methyl-d-aspartate pronociceptive systems leading to pain hypersensitivity and short-term tolerance. Because it is difficult in
Publikováno v:
Anesthesiology. 92:786-794
Background Tolerance to the analgesic effect of morphine complicates the management of chronic pain states. The authors studied the ability of the glycine/N-methyl-D-aspartate receptor antagonist (+)-HA966 to modify morphine tolerance in a rat model
Publikováno v:
Anesthesiology. 89:715-722
Background N-methyl-D-aspartate (NDMA) antagonists have minimal effects on acute nociception but block facilitated states of processing. In contrast, the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) antagonists decrease acute noxio
Publikováno v:
Anesthesiology. 115(4)
Background Buprenorphine, a partial μ-opioid receptor agonist and κ-opioid receptor antagonist, is an effective analgesic. The effects of buprenorphine on sleep have not been well characterized. This study tested the hypothesis that an antinocicept
Autor:
Tatsuo Yamamoto, Tony L. Yaksh
Publikováno v:
Anesthesiology. 77:757-763
Current thinking emphasizes that protracted small afferent input can evoke mechanisms that mediate a significant potentiation of spinal nociceptive processing and that this facilitory component has a unique pharmacology. To investigate the behavioral
Autor:
Joseph R. Holtman, Elzbieta P. Wala
Publikováno v:
Anesthesiology. 106(3)
Background Recently, it has been appreciated that in addition to their antinociceptive properties, opioid analgesics also can enhance pain sensitivity (opioid-induced hyperalgesia [OIH]). OIH may enhance preexisting pain and contribute to dose escala
Publikováno v:
Anesthesiology. 102(4)
Background Opioid analgesic tolerance is a pharmacologic phenomenon involving the mechanisms of cellular adaptation. Central glucocorticoid receptors (GRs) have been implicated in the cellular mechanism of neuronal plasticity that has many cellular s
Autor:
Carlo Pancaro, James C. Eisenach, Michelle Vincler, Frédéric Duflo, Xinhui Li, Carsten Bantel
Publikováno v:
Anesthesiology. 97(3)
Background Previous studies suggest that the alpha adrenoceptor subtype is the target for spinally administered alpha -adrenergic agonists, clonidine, for pain relief. However, ST 91, a preferential alpha adrenoceptor subtype agonist, induces antinoc