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Autor:
David Roberson, Teri A. Herbert, Chi Fei Wang, Aya A. Mitani, Clifford J. Woolf, Michelino Puopolo, Alexander M. Binshtok, Ging Kuo Wang, Gehoon Chung, Dong-Hoon Kim, Seog Bae Oh, Bruce P. Bean, Peter Gerner, Suzuko Suzuki
Publikováno v:
Anesthesiology. 111:127-137
Background Nociceptive-selective local anesthesia is produced by entry of the permanently charged lidocaine-derivative QX-314 into nociceptors when coadministered with capsaicin, a transient receptor potential vanilloid 1 (TRPV1) channel agonist. How
Publikováno v:
Anesthesiology. 107:305-311
Background: QX-314 is a quaternary lidocaine derivative considered to be devoid of clinically useful local anesthetic activity. However, several reports document that extracellular QX-314 application affects action potentials. Hence, the authors test
Autor:
Yukari Sudoh, Mohammed A. Khan, Kamen Vlassakov, Peter Gerner, Ging Kuo Wang, Mustafa G. Mujtaba, Douglas C. Anthony
Publikováno v:
Anesthesiology. 96:1435-1442
Background The antidepressant amitriptyline is commonly used orally for the treatment of chronic pain, particularly neuropathic pain, which is thought to be caused by high-frequency ectopic discharge. Among its many properties, amitriptyline is a pot
Publikováno v:
Anesthesiology. 94:661-667
Background Amitriptyline, a tricyclic antidepressant, is frequently used orally for the management of chronic pain. To date there is no report of amitriptyline producing peripheral nerve blockade. The authors therefore investigated the local anesthet
Publikováno v:
Anesthesiology. 119(2)
Background: The acetylcholinesterase inhibitor, pyridostigmine, is prophylactically administered to mitigate the toxic effects of nerve gas poisoning. The authors tested the hypothesis that prolonged pyridostigmine administration can lead to neuromus
Autor:
Joyce M. Hotz, Robert T. Wilder, Megumi Uezono, Joanne M. Curley, Jenny Castillo, Charles B. Berde, Joseph Tigner, Mark Chasin, Robert Langer
Publikováno v:
Anesthesiology. 85:1157-1166
Background Previous work showed that incorporation of dexamethasone (0.05 weight/weight percentage) into bupivacaine microspheres prolonged blockade by eight to 13 times compared with that produced by bupivacaine microspheres alone. The determinants
Publikováno v:
Anesthesiology. 84:1129-1137
Background Recent evidence has suggested that the timing of administration of analgesic drugs could influence their efficacy by reducing the sensitization of the nervous system induced by the nociceptive inputs, but this concept of preemptive analges
Publikováno v:
Anesthesiology. 79:766-773
BACKGROUND Bupivacaine alone, or in combination with opioids, has been shown to provide adequate pain relief without motor paralysis. This study examined the effects of bupivacaine administered intrathecally on sympathetic efferent and A delta- and C
Publikováno v:
Anesthesiology. 78:155-162
BACKGROUND Midazolam is being selected increasingly for use in patients with cardiovascular compromise. Although clinical doses of midazolam have minimal effects on cardiac function, the influence of midazolam (and other benzodiazepine sedatives) on
Autor:
Tatsuo Yamamoto, Tony L. Yaksh
Publikováno v:
Anesthesiology. 77:757-763
Current thinking emphasizes that protracted small afferent input can evoke mechanisms that mediate a significant potentiation of spinal nociceptive processing and that this facilitory component has a unique pharmacology. To investigate the behavioral