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Publikováno v:
Anesthesiology. 132:1138-1150
BackgroundAs severe acute hypoxemia produces a rapid inhibition of the respiratory neuronal activity through a nonopioid mechanism, we have investigated in adult rats the effects of hypoxemia after fentanyl overdose-induced apnea on (1) autoresuscita
Publikováno v:
Anesthesiology. 132:1197-1211
Background Opioids can induce significant respiratory depression when administered as analgesics for the treatment of acute, postoperative, and chronic pain. There are currently no pharmacologic means of reversing opioid-induced respiratory depressio
Publikováno v:
Anesthesiology. 130:1017-1031
Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Opioid analgesics are widely used for treatment of acute, postoperative, and chronic pain. However, activation of opioid receptors can resu
Publikováno v:
Anesthesiology. 126:708-715
Background Cebranopadol is a first-in-class analgesic with agonist activity at classic opioid peptide receptors and the nociceptin/orphanin FQ peptide receptor. The authors compared the antinociceptive and respiratory depressant effects of cebranopad
Autor:
Katrin Kistner, Carla Nau, Peter W. Reeh, Andreas Leffler, Wolfgang Koppert, Florian Niedermirtl, Georg Frank
Publikováno v:
Anesthesiology. 116:1335-1346
Background Opioids induce analgesia mainly by inhibiting synaptic transmission via G protein-coupled opioid receptors. In addition to analgesia, buprenorphine induces a pronounced antihyperalgesia and is an effective adjuvant to local anesthetics. Th
Publikováno v:
Anesthesiology. 114:150-161
Background Sensory neuron opioid receptors are targets for spinal, epidural, and peripheral opioid application. Although local nerve growth factor (NGF) has been identified as a mediator of sensory neuron μ-opioid receptor (MOR) up-regulation, the s
Publikováno v:
Anesthesiology. 108:484-494
Background Opioid-induced hyperalgesia can develop rapidly after opioid exposure. Neuropathic pain and opioid-induced hyperalgesia share common pathophysiologic mechanisms. Gabapentin is effective for the management of neuropathic pain and may theref
Publikováno v:
Anesthesiology. 122(2)
Background:There is an unmet clinical need to develop a pharmacological therapy to counter opioid-induced respiratory depression without interfering with analgesia or behavior. Several studies have demonstrated that 5-HT1A receptor agonists alleviate
Publikováno v:
Anesthesiology. 102:421-428
Background Although opioids are unsurpassed analgesics, experimental and clinical studies suggest that opioids activate N-methyl-d-aspartate pronociceptive systems leading to pain hypersensitivity and short-term tolerance. Because it is difficult in
Publikováno v:
Anesthesiology. 97:1641-1644