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Autor:
Bengt Nellgård, David S. Warner, Masaya Kudo, Huaxin Sheng, Robert D. Pearlstein, G. Burkhard Mackensen
Publikováno v:
Anesthesiology. 93:1102-1106
Background Isoflurane improves outcome from near-complete forebrain ischemia in rats compared with fentanyl-nitrous oxide (N2O). Sympathetic ganglionic blockade with trimethaphan abolishes this beneficial effect. To evaluate whether anesthesia-relate
Autor:
H. Mayumi Homi, David S. Warner, Robert D. Pearlstein, Hilaty P. Grocott, T. Huaxin Sheng, Javier Mixco
Publikováno v:
Anesthesiology. 99(5)
Background Volatile anesthetics provide protection in experimental models of global cerebral ischemia. To date, all models evaluated have included profound systemic arterial hypotension as a component of the ischemic insult. This study was designed t
Publikováno v:
Anesthesiology. 79(5)
BACKGROUND Previously, the authors found that anesthetized diabetic dogs had increased cerebral blood flow (CBF) and oxygen consumption (CMRO2). These results may have been influenced by anesthesia or surgery. The aim of this study was to determine w
Autor:
David P. Archer, Pascal Labrecque, Jean Guy Villemure, Mirko Diksic, Jane L. Tyler, Alan C. Evans, Antoine M. Hakim, W. F. Casey, D. Trop, Ernst Meyer
Publikováno v:
Anesthesiology. 72(6)
Using positron emission tomography, cerebral blood flow (CBF) and cerebral blood volume (CBV) were measured after the addition of isoflurane (1.3 vols %, end-tidal concentration) to neuroleptanesthesia (fentanyl/droperidol) in hypocapnic baboons. The
Autor:
James R. Harp, Isabella Englebach, Christer Carlsson, M. Mehdi Keykhah, Yaw Safo, David S. Smith
Publikováno v:
Anesthesiology. 63:274-277
The authors examined the effects of large intravenous doses of sufentanil (5-160 micrograms/kg) on cerebral blood flow (CBF) and cerebral metabolic rate for oxygen (CMRO2) in rats. CBF and CMRO2 were measured by a modified Kety-Schmidt technique usin
Publikováno v:
Anesthesiology. 67:314-319
Cerebral blood flow (CBF) and cerebral oxygen consumption (CMRO2) were measured, and electroencephalogram (EEG) was recorded in young (6-month-old) and aged (28-month-old) rats during ventilation with 70% N2O/30% O2 and following fentanyl or midazola
Publikováno v:
Anesthesiology. 60:180-186
The effect of high-dose fentanyl on the cerebral vascular response to alterations in mean arterial blood pressure, arterial O2 tension (PaO2), and arterial CO2 tension (PaCO2) was studied in 28 mongrel dogs using the cerebral venous outflow technique
Publikováno v:
Anesthesiology. 61(5)
Sufentanil, a narcotic five to ten times more potent than fentanyl, reduces cortical cerebral blood flow and oxygen consumption in rats, with seizure activity occurring in some animals. However, the effects of sufentanil on blood flow and metabolism
Publikováno v:
Anesthesiology. 57(5)
There is considerable controversy with respect to the effects of narcotics on the cerebral blood flow (CBF) and the cerebral metabolic rate for oxygen (CMRo2). The present study examined the effects of high doses of intravenous fentanyl (25-400 micro
Publikováno v:
Anesthesiology. 70(3)
The effects of 3.0 mg.kg-1 fentanyl on cerebral and peripheral hemodynamics alone and when combined with subanesthetic doses of pentobarbital (4.0 mg.kg-1), were studied in 11 unanesthetized, newborn lambs, in whom catheters had been previously inser