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Publikováno v:
Anesthesiology
BackgroundAnesthetics aim to prevent memory of unpleasant experiences. The amygdala and dorsal anterior cingulate cortex participate in forging emotional and valence-driven memory formation. It was hypothesized that this circuitry maintains its role
Autor:
Yugo Tagaito, Naohito Shimoyama, Hiroshi Nagase, Satoshi Toyama, Tsuyoshi Saitoh, Masashi Yanagisawa, Megumi Shimoyama
Publikováno v:
Anesthesiology. 128:992-1003
Background Sleepiness and decrease in attention are dose-limiting side effects of opioids. The orexin/hypocretin system plays an important role in maintaining wakefulness. This study aimed to explore the potential of a nonpeptide orexin receptor agon
Dose–response and Cardiopulmonary Side Effects of the Novel Neuromuscular-blocking Drug CW002 in Man
Autor:
John J. Savarese, Peter M. Savard, Paul M. Heerdt, Jaideep K. Malhotra, Hiroshi Sunaga, Deena Godfrey, Joel S. Owen, Matthew T. Murrell, Michelle Steinkamp, Cynthia A. Lien
Publikováno v:
Anesthesiology. 125:1136-1143
BackgroundCW002 is a benzylisoquinolinium nondepolarizing neuromuscular-blocking drug found to be inactivated by cysteine in preclinical studies. The current study represents a dose escalation clinical trial designed to describe CW002 potency, durati
Autor:
J. Ullman, Eva Hagel, Eva Christensson, Anna Hårdemark Cedborg, Lars Eriksson, Malin Jonsson Fagerlund, Souren Mkrtchian, Anette Ebberyd, Åse Lodenius, Mika Scheinin
Publikováno v:
Anesthesiology. 125:700-715
Background In contrast to general anesthetics such as propofol, dexmedetomidine when used for sedation has been put forward as a drug with minimal effects on respiration. To obtain a more comprehensive understanding of the regulation of breathing dur
Publikováno v:
Anesthesiology. 128(3)
Background This study tests the hypothesis that sevoflurane blocks long-term potentiation only if it is present during the high-frequency stimulation that induces long-term potentiation. Methods Long-term potentiation, an electrophysiologic correlate
Publikováno v:
Anesthesiology. 125(3)
Background Evidence indicates that the anesthetic-sparing effects of α2-adrenergic receptor (AR) agonists involve α2A-AR heteroreceptors on nonadrenergic neurons. Since volatile anesthetics inhibit neurotransmitter release by reducing synaptic vesi
Autor:
B Gallix, Boris Jung, S. Aufort, Stephanie Nougaret, Samir Jaber, Gregoire Mercier, Gerald Chanques, Moussa Cisse, Djillali Annane
Publikováno v:
Anesthesiology. 115:334-343
Background : Assessment and management of septic shock associated adrenal function remain controversial. The aim of this study was to explore the prognostic value of adrenal gland volume in adults with septic shock. Methods : A short cosyntropin test