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Publikováno v:
Anesthesiology
The prevention of perioperative neurocognitive disorders is a priority for patients, families, clinicians, and researchers. Given the multiple risk factors present throughout the perioperative period, a multicomponent preventative approach may be mos
Publikováno v:
Anesthesiology. 136:148-161
Background The relationship between late clinical outcomes after injury and early dynamic changes between fibrinolytic states is not fully understood. The authors hypothesized that temporal transitions in fibrinolysis states using rotational thromboe
Autor:
Cheryl L. Maier, Roman M. Sniecinski
Publikováno v:
Anesthesiology
From preoperative medications to intraoperative needs to postoperative thromboprophylaxis, anticoagulants are encountered throughout the perioperative period. This review focuses on coagulation testing clinicians utilize to monitor the effects of the
Publikováno v:
Anesthesiology. 135:350-365
Opioids are a mainstay of treatment for pain worldwide. Pruritus, a common side effect of opioids, is a patient dissatisfier that limits their use in many clinical settings. Both parenteral and neuraxial administration of opioids frequently evoke pru
Autor:
Luis Enrique Chaparro, Henrik Kehlet, Meg Carley, Manon Choinière, Ian Gilron, R Andrew Moore, Elizabeth Van Den Kerkhof
Publikováno v:
Anesthesiology
BackgroundChronic postsurgical pain can severely impair patient health and quality of life. This systematic review update evaluated the effectiveness of systemic drugs to prevent chronic postsurgical pain.MethodsThe authors included double-blind, pla
Publikováno v:
Anesthesiology. 135:928-930
Autor:
Yukiko Omura, Elnaz Lashgari, Robert F Herkenham, Siamak Salavatian, Erica A. Dale, Jasmine Kipke, Uri Maoz, Andrew Shea Afyouni, Kimberly Howard-Quijano, Aman Mahajan, Christian Wooten
Publikováno v:
Anesthesiology
Background Cardiac sympathoexcitation leads to ventricular arrhythmias. Spinal anesthesia modulates sympathetic output and can be cardioprotective. However, its effect on the cardio-spinal reflexes and network interactions in the dorsal horn cardiac
Publikováno v:
Anesthesiology. 134:88-102
Background Although the widely used single L-enantiomers of local anesthetics have less toxic effects on the cardiovascular and central nervous systems, the mechanisms mediating their antinociceptive actions are not well understood. The authors hypot
Publikováno v:
Anesthesiology. 134:645-659
Opioids form an important component of general anesthesia and perioperative analgesia. Discharge opioid prescriptions are identified as a contributor for persistent opioid use and diversion. In parallel, there is increased enthusiasm to advocate opio
Publikováno v:
Anesthesiology. 133:534-547
Background According to the “three-compartment” model of ventilation-perfusion () inequality, increased scatter in the lung under general anesthesia is reflected in increased alveolar deadspace fraction (Vda/Va) customarily measured using end-tid