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Publikováno v:
Anesthesiology. 134:617-625
Background The median effective dose of ropivacaine required for producing an effective costoclavicular block has not yet been determined. The authors conducted this dose-finding study with the objective of determining the median effective dose of 0.
Autor:
Reine Ibala, Shubham Chamadia, Oluwaseun Akeju, Jennifer Mekonnen, Jason Z. Qu, Eunice Hahm, Juan C Pedemonte, Joseph J. Locascio, Jacob Gitlin, Katia M Colon, Breanna R Ethridge
Publikováno v:
Anesthesiology. 133:1021-1028
Background Ketamine is a dissociative anesthetic with analgesic properties. Ketamine’s analgesic properties have been suggested to result from its dissociative properties. To the authors’ knowledge, this postulate is unsubstantiated. The authors
Publikováno v:
Anesthesiology. 133:439-457
The recent demonstration of the significant reduction in mortality in patients with septic shock treated with adjunctive glucocorticoids combined with fludrocortisone and the effectiveness of angiotensin II in treating vasodilatory shock have renewed
Autor:
Armando Teixeira-Pinto, Isaura Tavares, Ana Costa, Marília Sousa, Steven P. Wilson, Isabel Martins, Carlos Reguenga
Publikováno v:
Anesthesiology. 133:628-644
Background Increased descending pain facilitation accounts for opioid-induced hyperalgesia, but the underlying mechanisms remain elusive. Given the role of µ-opioid receptors in opioid-induced hyperalgesia in animals, the authors hypothesized that t
Autor:
Jaime B. Hyman, S.S. Fenske, Stephanie V. Blank, L. Rosen, Sylvie B. Polsky, Hung-Mo Lin, Peter J. Taub, Beatriz Cole, Chang Park, Charles Ascher-Walsh, Matthew Hartnett, Rachel L. Barr Grzesh, Vijay Palvia, Samuel DeMaria
Publikováno v:
Anesthesiology. 132:1419-1428
BackgroundPostdischarge nausea and vomiting after ambulatory surgery is a common problem that is not adequately addressed in current practice. This prospective, randomized, double-blind, parallel-group, placebo-controlled study was designed to test t
Autor:
Paul L. Feldman
Publikováno v:
Anesthesiology. 132:1229-1234
Design, Synthesis, and Pharmacological Evaluation of Ultrashort- to Long-acting Opioid Analgetics. By Feldman PL, James MK, Brackeen MF, Bilotta JM, Schuster SV, Lahey AP, Lutz MW, Johnson MR, Leighton HJ. J Med Chem 1991; 34:2202-8. Copyright 1991 A
Autor:
Steven Mcguigan, Will Woods, David T. J. Liley, Suresh D. Muthukumaraswamy, Levin Kuhlmann, Andria Pelentritou, John R. Cormack
Publikováno v:
Anesthesiology. 132:1017-1033
Background Investigations of the electrophysiology of gaseous anesthetics xenon and nitrous oxide are limited revealing inconsistent frequency-dependent alterations in spectral power and functional connectivity. Here, the authors describe the effects
Autor:
Jennifer H. Walsh, Malin Jonsson Fagerlund, Mika Scheinin, David R. Hillman, Åse Lodenius, Kathleen J. Maddison, Brad K. Lawther, Lars Eriksson, Peter R. Eastwood
Publikováno v:
Anesthesiology. 131:962-973
Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Dexmedetomidine is a sedative promoted as having minimal impact on ventilatory drive or upper airway muscle activity. However, a trial rece
Autor:
Oliver Bagshaw, Brian J. Anderson
Publikováno v:
Anesthesiology. 131:164-185
Propofol administered in conjunction with an opioid such as remifentanil is used to provide total intravenous anesthesia for children. Drugs can be given as infusion controlled manually by the physician or as automated target-controlled infusion that
Autor:
Alejandro Fernandez-Escobar, Jeremy M Sivak, C. Justin Lee, Amy J. Ramsey, Junhui Wang, Beverley A. Orser, Nathan K. Chan, Junsung Woo, Dian Shi Wang, Darren Chan, Sinziana Avramescu, Robert P. Bonin, Fariya Mostafa, Irene Lecker, Yu-Feng Xie, Gang Lei, Kirusanthy Kaneshwaran
Publikováno v:
Anesthesiology. 129:477-489
What We Already Know about This Topic What This Article Tells Us That Is New Background Postoperative delirium is associated with poor long-term outcomes and increased mortality. General anesthetic drugs may contribute to delirium because they increa