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Autor:
Kasun Wickramarachchi, Nicole Sheridan, Simon Yates, Scott McAlister, Forbes McGain, Brandon Chan
Publikováno v:
Anesthesiology. 135:976-991
Background Health care itself contributes to climate change. Anesthesia is a “carbon hotspot,” yet few data exist to compare anesthetic choices. The authors examined the carbon dioxide equivalent emissions associated with general anesthesia, spin
Publikováno v:
Anesthesiology. 134:88-102
Background Although the widely used single L-enantiomers of local anesthetics have less toxic effects on the cardiovascular and central nervous systems, the mechanisms mediating their antinociceptive actions are not well understood. The authors hypot
Publikováno v:
Anesthesiology. 133:534-547
Background According to the “three-compartment” model of ventilation-perfusion () inequality, increased scatter in the lung under general anesthesia is reflected in increased alveolar deadspace fraction (Vda/Va) customarily measured using end-tid
Autor:
Yan Liang, Daniel K. Mulkey, Mengchan Ou, Tao Zhu, Jin Liu, Wenling Zhao, Yang Yaoxin, Cheng Zhou, Lamu Zhuoma
Publikováno v:
Anesthesiology. 133:824-838
Background Volatile anesthetics moderately depress respiratory function at clinically relevant concentrations. Phox2b-expressing chemosensitive neurons in the retrotrapezoid nucleus, a respiratory control center, are activated by isoflurane, but the
Publikováno v:
Anesthesiology. 133:439-457
The recent demonstration of the significant reduction in mortality in patients with septic shock treated with adjunctive glucocorticoids combined with fludrocortisone and the effectiveness of angiotensin II in treating vasodilatory shock have renewed
Autor:
Patric J. Perez, Meina Wang, Elizabeth Hunter, Christy D. Gray, Caroline Krall, John Skinner, Roger A. Johns, Michele L. Schaefer, Xiaoning Sun
Publikováno v:
Anesthesiology
Background Experimental evidence shows postnatal exposure to anesthesia negatively affects brain development. The PDZ2 domain, mediating protein–protein interactions of the postsynaptic density-95 protein, serves as a molecular target for several i
Autor:
Armando Teixeira-Pinto, Isaura Tavares, Ana Costa, Marília Sousa, Steven P. Wilson, Isabel Martins, Carlos Reguenga
Publikováno v:
Anesthesiology. 133:628-644
Background Increased descending pain facilitation accounts for opioid-induced hyperalgesia, but the underlying mechanisms remain elusive. Given the role of µ-opioid receptors in opioid-induced hyperalgesia in animals, the authors hypothesized that t
Publikováno v:
Anesthesiology. 133:393-407
Background Clinical studies have shown that dexmedetomidine ameliorates cognitive decline in both the postoperative and critical care settings. This study determined the mechanism(s) for the benefit provided by dexmedetomidine in a medical illness in
Autor:
Yiqiao Wang, Hailong Dong, Ying Wu, Wenzhi Sun, Gaolin Qiu, Long Li, Ji Hu, Zeyong Yang, Xiaona Zhu, Yuanhai Li
Publikováno v:
Anesthesiology. 133:377-392
Background Dexmedetomidine induces a sedative response that is associated with rapid arousal. To elucidate the underlying mechanisms, the authors hypothesized that dexmedetomidine increases the activity of dopaminergic neurons in the ventral tegmenta
Autor:
Steven Mcguigan, Will Woods, David T. J. Liley, Suresh D. Muthukumaraswamy, Levin Kuhlmann, Andria Pelentritou, John R. Cormack
Publikováno v:
Anesthesiology. 132:1017-1033
Background Investigations of the electrophysiology of gaseous anesthetics xenon and nitrous oxide are limited revealing inconsistent frequency-dependent alterations in spectral power and functional connectivity. Here, the authors describe the effects