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Author/Creator:
Nathalie Boichut, Ngai Liu, Lucie Vettoretti, Grégory Tio, T. Chazot, Melanie Claveau, Nicolas Mahr, Guillaume Besch, Sebastien Pili-Floury, Yannis Bouhake, Emmanuel Samain, Gilles Chopard
Published in:
Anesthesia & Analgesia. 133:837-847
BACKGROUND The aim of the study was to investigate whether closed-loop compared to manual bispectral index (BIS)-guided target-controlled infusion of propofol and remifentanil could decrease the incidence of postoperative neurocognitive disorders aft
Author/Creator:
Ronald E Angona, Alycia Wanat-Hawthorne, Kenichi A. Tanaka, Michael P. Eaton, Changyong Feng
Published in:
Anesthesia & Analgesia. 133:1180-1186
Background Heparin-induced thrombocytopenia (HIT) is an immune-mediated adverse reaction to heparin. Patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) are routinely anticoagulated with heparin before the initiation of bypass. Hepa
Author/Creator:
Edward G. Soltesz, Mee Jee Lee, Guangmei Mao, Steve Leung, Andra E. Duncan, Charles S. Tannenbaum, Yuan Jia, Huseyin Oguz Yilmaz, Ilker Ince
Published in:
Anesthesia & Analgesia. 133:906-914
BACKGROUND Cardiac surgery with cardiopulmonary bypass induces a profound inflammatory response that, when severe, can lead to multiorgan system dysfunction. Preliminary data suggest that administration of hydroxyethyl starch (HES) solutions may miti
Author/Creator:
Candida L Goodnough, Kelly Sheppard, Sophia Turkmani-Bazzi, Brita Mittal, Erin Bushell
Published in:
Anesth Analg
Epidermolysis bullosa (EB) is a group of rare, inherited diseases characterized by skin fragility and multiorgan system involvement that presents many anesthetic challenges. Although the literature regarding anesthetic management focuses primarily on
Author/Creator:
Mouna Ben Rehouma, Jean-Xavier Mazoit, Leila Hamdi, Mickael Soued, Toni Kfoury, Meriem Bouchouareb, Dan Benhamou
Published in:
Anesthesia & Analgesia. 133:1311-1320
Background Visceral and parietal peritoneum layers have different sensory innervations. Most visceral peritoneum sensory information is conveyed via the vagus nerve to the nucleus of the solitary tract (NTS). We already showed in animal models that i
Author/Creator:
Atsushi Sawada, Yusuke Yoshikawa, Natsumi Kii, Michiaki Yamakage, Shunsuke Tachibana
Published in:
Anesthesia & Analgesia. 134:869-880
BACKGROUND Traumatic brain injury (TBI) initiates immune responses involving infiltration of monocyte-derived macrophages (MDMs) in the injured brain tissue. These MDMs play a key role in perioperative neurocognitive disorders (PNDs). We tested the h
Published in:
Anesthesia & Analgesia. 133:1028-1035
Background The adenosine triphosphate-binding cassette, subfamily B, member 1 gene (ABCB1) encodes P-glycoprotein (P-gp) that influences the intracellular transport of solutes including endogenous opioid peptides. The primary objective of this study
Author/Creator:
Emily G. Reynolds, Emily E Sharpe, Monica W. Harbell, Lauren M Van Decar, Molly B Kraus, Heidi E. Kosiorek
Published in:
Anesthesia & Analgesia. 134:82-89
Diabetes insipidus (DI) is an uncommon perioperative complication that can occur secondary to medications or surgical manipulation and can cause significant hypovolemia and electrolyte abnormalities. We reviewed and evaluated the current literature a
Potential for Kappa-Opioid Receptor Agonists to Engineer Nonaddictive Analgesics: A Narrative Review
Published in:
Anesth Analg
A serious adverse effect of prescription opioid analgesics is addiction, both to these analgesics and to illicit drugs like heroin that also activate the mu opioid receptor (MOR). Opioid Use Disorder (OUD) and opioid overdose deaths represent a curre
Author/Creator:
Christian Zöllner, Katharina Roeher, Janna Gruetzmacher, Christoph Duckstein, Ursula Kahl, Maren Vens, Marlene Fischer, Matthias S. Goepfert, Yuanyuan Yu, Leah Schirren, Franziska Pollok, Maja Menke
Published in:
Anesthesia & Analgesia. 132:420-429
BACKGROUND Diastolic dysfunction is a risk factor for postoperative major cardiovascular events. During anesthesia, patients with diastolic dysfunction might experience impaired hemodynamic function and worsening of diastolic function, which in turn,