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Autor:
Andrew R. Fischer, Elliot Israel, Joan C. Callery, Mitchell Rosenberg, Craig M. Lilly, Jo Shapiro, Paul H. Rubin, Judith Cohn, Jeffrey M. Drazen
Publikováno v:
American Review of Respiratory Disease. 148:1447-1451
A subset of persons with asthma develop bronchospasm, naso-ocular, gastrointestinal, and/or dermal reactions after ingesting aspirin (ASA) or agents with the capacity to inhibit cyclooxygenase. The bronchopulmonary reactions have been associated with
Publikováno v:
American Review of Respiratory Disease. 148:1233-1237
We have studied the effects on FEV1 of inhaled capsaicin in concentrations of 3 x 10(-6) to 3 x 10(-1) mg/ml and methacholine (1 to 16 mg/ml) in 15 heart-lung transplant (HLT) patients who had undergone recent transbronchial lung biopsy to determine
Publikováno v:
American Review of Respiratory Disease. 148:940-943
It has been reported that acetaldehyde may be a main factor of alcohol-induced bronchoconstriction in Japanese patients with asthma. The purpose of this study was to investigate the direct action of acetaldehyde on the airway in asthmatic and healthy
Autor:
Richard C Boucher, Oscar Ramirez, Malcolm King, Michael R Knowles, N. Church, J. G. Zayas, Robert P. Tomkiewicz, Ernst M. App
Publikováno v:
American Review of Respiratory Disease. 148:1002-1007
Amiloride inhalation as treatment for cystic fibrosis (CF) lung disease has been shown in independent studies to increase mucus clearance by ciliary and/or cough action and to retard the decline in lung function. It is hypothesized that amiloride the
Publikováno v:
American Review of Respiratory Disease. 148:707-712
It has been suggested that regular treatment with high doses of beta 2-agonists might result in poorer control of asthma and increased bronchial responsiveness. We have examined change in FEV1 (delta FEV1), bronchial reactivity, peak expiratory flow
Autor:
Motohiko Miura, K. Kimura, Masakazu Ichinose, Tamotsu Takishima, Kunio Shirato, Tsuneyuki Takahashi, Hiroshi Inoue
Publikováno v:
American Review of Respiratory Disease. 148:431-434
We examined the effect of ibudilast, an antiasthma drug, on neurogenic microvascular leakage in guinea-pig airways by measuring extravasation of Evans blue dye. After intravenous pretreatment with atropine (1 mg/kg) and propranolol (1 mg/kg), bilater
Publikováno v:
American Review of Respiratory Disease. 147:1472-1476
Allergen challenge is associated with an increased excretion of urinary leukotriene E4. The source of this increase is unknown, although the lack of effect of inhaled beta-agonists and sodium cromoglycate suggests that airway mast cells may not be in
Publikováno v:
Scopus-Elsevier
Patients with asthma generate increased amounts of reactive oxygen species (ROS) from peripheral blood cells and cells recovered by bronchoalveolar lavage (BAL). ROS produce many of the pathophysiologic changes associated with asthma and may contribu
Autor:
F.B. Michel, Ph. Godard, Jean Bousquet, Pascal Chanez, Alison M. Campbell, I. Couret, A M Vignola
Publikováno v:
American Review of Respiratory Disease. 147:529-534
Airways epithelial cells may be involved in the pathogenesis of asthma, but their role remains to be determined. Epithelial cells can release large amounts of 15-hydroxy-eicosatetranoic acid (15-HETE) and smaller amounts of prostaglandin E2 (PGE2) as
Publikováno v:
American Review of Respiratory Disease. 147:307-313
Previously it was demonstrated that during delayed-type hypersensitivity reactions (DTH) to picryl chloride (PCl) in murine lungs, as a model for cellular IgE-independent immunity, tracheal hyperreactivity and increased pulmonary resistance are induc