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Publikováno v:
American Review of Respiratory Disease. 148:1233-1237
We have studied the effects on FEV1 of inhaled capsaicin in concentrations of 3 x 10(-6) to 3 x 10(-1) mg/ml and methacholine (1 to 16 mg/ml) in 15 heart-lung transplant (HLT) patients who had undergone recent transbronchial lung biopsy to determine
Publikováno v:
American Review of Respiratory Disease. 148:940-943
It has been reported that acetaldehyde may be a main factor of alcohol-induced bronchoconstriction in Japanese patients with asthma. The purpose of this study was to investigate the direct action of acetaldehyde on the airway in asthmatic and healthy
Publikováno v:
American Review of Respiratory Disease. 148:116-122
Tests of nonspecific airway hyperresponsiveness are frequently used in the study of asthma both in the clinical settings and in epidemiologic studies. However, standard methods for characterizing individual tests and comparing results between subgrou
Publikováno v:
American Review of Respiratory Disease. 147:1472-1476
Allergen challenge is associated with an increased excretion of urinary leukotriene E4. The source of this increase is unknown, although the lack of effect of inhaled beta-agonists and sodium cromoglycate suggests that airway mast cells may not be in
Autor:
Steven J. Ackerman, Anthony J. Coyle, Peter F. Weller, Charles G. Irvin, Gary L. Larsen, John Freed, Derek A. Uchida
Publikováno v:
American Review of Respiratory Disease. 147:982-988
Major basic protein (MBP) is a highly cationic protein found in the granules of eosinophils. It has been postulated that MBP may participate in the pathogenesis of airway hyperresponsiveness exhibited by asthmatic patients. Accordingly, we used a rat
Publikováno v:
American Review of Respiratory Disease, 147(3), 553-558
In contrast to methacholine, a stimulus that induces airway constriction mainly by ''direct'' stimulation of airway smooth muscle cells, AMP airway responsiveness reflects ''indirectly'' induced airway narrowing via inflammatory or neural reflex mech
Publikováno v:
American Review of Respiratory Disease. 147:518-523
Theophylline, a drug used for the treatment of asthma, is recognized as an immunomodulator affecting T-lymphocytes both in vitro and in vivo. The effect of slow-release theophylline (Uniphyllin Continus) on the late asthmatic response (LAR) has been
Autor:
Bohdan M. Pichurko, Roland H. Ingram, John J. Godleski, Edward P. Ingenito, Lawrence B. Pliss
Publikováno v:
American Review of Respiratory Disease. 146:1315-1319
Paralyzed mechanically ventilated guinea pigs constricted to a similar degree by either isocapnic hyperpnea or antigen challenge display significantly different lung resistance (RL) volume history responses to a deep breath. We compared bronchoalveol
Autor:
B. J. O. Wong, Paul M. O'Byrne, Jerry Dolovich, F. E. Hargreave, L. Gontovnick, E H Ramsdale, Judah A. Denburg
Publikováno v:
American Review of Respiratory Disease. 146:1156-1160
Formoterol is a new long-acting beta 2-agonist. We compared the protective effect of 24 micrograms formoterol with 200 micrograms beclomethasone and placebo on inhaled allergen-induced asthmatic responses in mild stable asthmatic subjects. We measure
Publikováno v:
American Review of Respiratory Disease. 146:895-899
To characterize airway responses in a population sample, respiratory symptoms, smoking habits, and changes in FEV1 (delta FEV1) to inhaled methacholine (maximal cumulative dose of 196 mumol or maximal decrease in FEV1 of 50%) were recorded in 201 sub