Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Carl W. White"'
Autor:
Tara B. Hendry-Hofer, Matthew D. McGraw, Wesley W. Holmes, Danielle C. Paradiso, Livia A. Veress, Jacqueline S. Rioux, Russell W. Smith, Dana R. Anderson, Carl W. White, Paul R. Houin, Joan E. Loader, Marilyn M. Dysart, Rhonda B. Garlick
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 58:696-705
Inhalation of powerful chemical agents, such as sulfur mustard (SM), can have debilitating pulmonary consequences, such as bronchiolitis obliterans (BO) and parenchymal fibrosis (PF). The underlying pathogenesis of disorders after SM inhalation is no
Autor:
Gates B. Roe, Matthew D. McGraw, Angela L. Murphy, Obiefuna C. Okponyia, Livia A. Veress, Marilyn M. Dysart, Jacqueline S. Rioux, Rhonda B. Garlick, Carl W. White
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 58:107-116
Chlorine is a highly reactive gas that can cause significant injury when inhaled. Unfortunately, its use as a chemical weapon has increased in recent years. Massive chlorine inhalation can cause death within 4 hours of exposure. Survivors usually req
Publikováno v:
American journal of respiratory cell and molecular biology. 56(1)
Cell therapy has the potential to cure disease through replacement of malfunctioning cells. Although the tissue stem cell (TSC) is thought to be the optimal therapeutic cell, transplantation of TSC/progenitor cell mixtures has saved lives. We previou
Autor:
Carl W. White, Tara B. Hendry-Hofer, Jacqueline S. Rioux, Rhonda B. Garlick, Livia A. Veress, Joan E. Loader
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 48:439-447
Sulfur mustard (SM) inhalation causes the rare but life-threatening disorder of plastic bronchitis, characterized by bronchial cast formation, resulting in severe airway obstruction that can lead to respiratory failure and death. Mortality in those r
Autor:
Joan E. Loader, Tara B. Hendry-Hofer, Brian J. Day, Heidi C. O'Neill, David J. Orlicky, Carl W. White
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 45:323-331
The inhalation of sulfur mustard (SM) causes substantial deposition in the nasal region. However, specific injury has not been characterized. 2-chloroethyl ethyl sulfide (CEES) is an SM analogue used to model injury and screen potential therapeutics.
Autor:
Tara B. Hendry-Hofer, Nichole Reisdorph, Joshua D. Chandler, Joan E. Loader, Olivier Mozziconacci, Carl W. White, Shama Ahmad, Brian J. Day, Roger Powell, Livia A. Veress, William C. Claycomb, Aftab Ahmad, Christian Schöneich
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Autopsy specimens from human victims or experimental animals that die due to acute chlorine gas exposure present features of cardiovascular pathology. We demonstrate acute chlorine inhalation–induced reduction in heart rate and oxygen saturation in
Autor:
Carl W. White, Aftab Ahmad, Kurt R. Stenmark, Corrie B. Allen, Shama Ahmad, Evgenia V. Gerasimovskaya
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 28:179-187
Hypoxic preconditioning is protective against oxidant-related thelial survival and growth are likely to be involved in the damage in various organs, such as the heart. We previously pathogenesis of BPD. Hyperoxia can induce injury and showed that rat
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 25:226-232
Peroxiredoxin (Prx) is an important antioxidant defense enzyme that reduces hydrogen peroxide to molecular oxygen by using reducing equivalents from thioredoxin. We report that lung Prx I messenger RNA (mRNA) is specifically upregulated by oxygen. Th
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 25:51-59
The mechanisms whereby lung adaptation to hyperoxia occurs in the newborn period are incompletely understood. Pulmonary surfactant has been implicated in lung protection against hyperoxic injury, and elevated expression of certain surfactant proteins
Autor:
Carl W. White, Shama Ahmad, Tara B. Hendry-Hofer, Stacy M. Miller, Kenneth C. Malcolm, Jerome Schaack, Aftab Ahmad
Publikováno v:
American journal of respiratory cell and molecular biology. 49(1)
Hypoxia-inducible transcription factors HIF-1α and HIF-2α can contribute to pulmonary hypertension and vascular remodeling, but their mechanisms remain unknown. This study investigated the role of HIF-1α and HIF-2α in pulmonary artery endothelial