Zobrazeno 1 - 10
of 21
pro vyhledávání: '"11"'
Autor:
Pierre Oudet, Anne Schneider, Florence Cave-Riant, François Alla, Benoit Cuillerier, Nadine Martinet, Michèle Beau-Faller, Marie Pierre Gaub, Christian Bronner
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 27:495-502
Genetic mechanisms underlying origin and progression of lung cancer are still poorly understood, despite the numerous studies which identified many genomic alterations. Using polymorphic microsatellites, allelic imbalances have been frequently found
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 15:693-702
Over the last 20 years, fibrotic lung diseases have been treated with corticosteroids or cytotoxic immunosuppressants with very little change in morbidity and mortality outcomes (1). In order to find more effective treatment regimens, many laboratori
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 47:245-252
Chaperonin 60.1 from Mycobacterium tuberculosis suppressed allergic lung inflammation and bronchial hyperresponsiveness in mice by a mechanism that is yet to be clarified. To investigate the possible antiinflammatory mechanism(s) of action of Cpn60.1
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 46:842-846
We previously reported that plasminogen activator inhibitor (PAI)-1 deficiency prevents collagen deposition in the airways of ovalbumin (OVA)-challenged mice. In this study, we explored the therapeutic utility of blocking PAI-1 in preventing airway r
Autor:
Raul Godoy, Alberto Lázaro, Luis Puente-Maestu, Alberto Tejedor, Ana Torres, Alvar Agusti, Alicia Ferreira, José Pérez-Parra, Nicolas Moreno
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 40:746-750
Skeletal muscle dysfunction (SMD) is frequent in patients with chronic obstructive pulmonary disease (COPD). Mitochondrial abnormalities appear to play a role in the pathogenesis of SMD. The mitochondrion permeability transition pore (MPTP) facilitat
Respiratory Epithelial Gene Expression in Patients with Mild and Severe Cystic Fibrosis Lung Disease
Autor:
Jeffrey B. Reynolds, Pamela L. Zeitlin, Christian A. Merlo, Jerry Wright, Joe G.N. Garcia, Michael P. Boyle, William B. Guggino
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 35:327-336
Despite having identical cystic fibrosis transmembrane conductance regulator genotypes, individuals with ΔF508 homozygous cystic fibrosis (CF) demonstrate significant variability in severity of pulmonary disease. This investigation used high-density
Autor:
Mark Barger, Lori A. Battelli, Michael L. Kashon, Joginder Nath, Mohamed Ghanem, J. Y. C. Ma, Vincent Castranova, Ann F. Hubbs, Dale W. Porter, Val Vallyathan
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 31:171-183
Cytochrome P4501A1 (CYP1A1) metabolizes polycyclic aromatic hydrocarbons in cigarette smoke to DNA-binding reactive intermediates associated with carcinogenesis. Epidemiologic studies indicate that the majority of coal miners are smokers but have a l
Autor:
Benoit Wallaert, Marie-Laure Franco-Montoya, Philippe Gosset, Alain Harf, Emmanuelle Lechapt-Zalcman, Hassan Lemjabbar, Chantal Lafuma
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 20:903-913
Alveolar macrophages (AM) express gelatinase B, a member of the matrix metalloproteinase family involved in the degradation and remodeling of extracellular matrix components. We evaluated the expression of gelatinase B in the course of idiopathic pul
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 18:60-65
Human interleukin 13 (IL-13) is a cytokine that has a profound effect on primary immune cells by inducing immunoglobulin production, proliferation of B cells, and the differentiation of cells of the monocytic lineage. IL-13 can inhibit the production
Autor:
Rodney J. Folz
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 20:1097-1099
Dose-intensive chemotherapy combined with localized or total body irradiation (TBI) followed by autologous or allogeneic hematologic stem-cell transplantation is increasingly being used to treat a number of solid tissue and hematologic malignancies.