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Autor:
Ru-Jeng Teng, Girija G. Konduri, Ujala Rana, Adeleye J. Afolayan, Abdul K. Parchur, Megha Sharma, Chintamani Joshi, Amit Joshi, Teresa Michalkiewicz
Publikováno v:
Am J Respir Cell Mol Biol
Impaired angiogenesis function in pulmonary artery endothelial cells (PAEC) contributes to persistent pulmonary hypertension of the newborn (PPHN). Decreased nitric oxide (NO) amounts in PPHN lead to impaired mitochondrial biogenesis and angiogenesis
Autor:
Denielli da Silva Goncalves Bos, Robert Szulcek, Frances S. de Man, Xiaoke Pan, Maria Catalina Gomez-Puerto, Willem J. van der Laarse, Ingrid Schalij, Anton Vonk Noordegraaf, Harm Jan Bogaard, Roy E. J. Schiepers, Eva L. Peters, Stine Andersen, Asger Andersen, Marie-José Goumans, Xiao-Qing Sun, Julie Birkmose Axelsen, Kondababu Kurakula
Publikováno v:
Sun, X-Q, Peters, E L, Schalij, I, Axelsen, J B, Andersen, S, Kurakula, K, Gomez-Puerto, M C, Szulcek, R, Pan, X, da Silva Goncalves Bos, D, Schiepers, R E, Andersen, A, Goumans, M-J, Vonk Noordegraaf, A, van der Laarse, W J, de Man, F S & Bogaard, H J 2021, ' Increased MAO-A Activity Promotes Progression of Pulmonary Arterial Hypertension ', American Journal of Respiratory Cell and Molecular Biology (Online), vol. 64, no. 3, pp. 331-343 . https://doi.org/10.1165/rcmb.2020-0105OC
American Journal of Respiratory Cell and Molecular Biology, 64(3), 331-343. American Thoracic Society
Sun, X-Q, Peters, E L, Schalij, I, Axelsen, J B, Andersen, S, Kurakula, K, Gomez-Puerto, M C, Szulcek, R, Pan, X, da Silva Goncalves Bos, D, Schiepers, R E J, Andersen, A, Goumans, M-J, Noordegraaf, A V, van der Laarse, W J, de Man, F S & Bogaard, H J 2021, ' Increased MAO-A activity promotes progression of pulmonary arterial hypertension ', American Journal of Respiratory Cell and Molecular Biology, vol. 64, no. 3, pp. 331-343 . https://doi.org/10.1165/rcmb.2020-0105OC, https://doi.org/10.1165/rcmb.2020-0105OC
American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory Cell and Molecular Biology, 64(3), 331-343. AMER THORACIC SOC
American Journal of Respiratory Cell and Molecular Biology, 64(3), 331-343. American Thoracic Society
Sun, X-Q, Peters, E L, Schalij, I, Axelsen, J B, Andersen, S, Kurakula, K, Gomez-Puerto, M C, Szulcek, R, Pan, X, da Silva Goncalves Bos, D, Schiepers, R E J, Andersen, A, Goumans, M-J, Noordegraaf, A V, van der Laarse, W J, de Man, F S & Bogaard, H J 2021, ' Increased MAO-A activity promotes progression of pulmonary arterial hypertension ', American Journal of Respiratory Cell and Molecular Biology, vol. 64, no. 3, pp. 331-343 . https://doi.org/10.1165/rcmb.2020-0105OC, https://doi.org/10.1165/rcmb.2020-0105OC
American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory Cell and Molecular Biology, 64(3), 331-343. AMER THORACIC SOC
Monoamine oxidases (MAOs), a class of enzymes bound to the outer mitochondrial membrane, are important sources of reactive oxygen species. Increased MAO-A activity in endothelial cells and cardiomyocytes contributes to vascular dysfunction and progre
Autor:
Werner Seeger, Andreas Guenther, Natascha Sommer, Ingrid Henneke, Claudia F. Garcia-Castro, Alireza Saraji, Ralph T. Schermuly, Matthias Hecker, Katharina Schäfer, Stefan Hadzic, Norbert Weissmann, Nasim Alebrahimdehkordi, Akylbek Sydykov, Djuro Kosanovic, Hossein Ardeschir Ghofrani, Oleg Pak
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 65:226-228
Autor:
Matthias Ochs, Elena Lopez-Rodriguez
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 63:399-402
Autor:
Souheil El-Chemaly, Ehab A. Ayaub, Konstantin Tsoyi, Kevin Xiong, Yuanyuan Shi, Raju V. V. Tatituri, Sarah G. Chu, Bonna Ith, Fong-Fu Hsu, Xiaoliang Liang, Derek E. Byers, Ivan O. Rosas, Julian A. Villalba, Edy Y. Kim
Publikováno v:
Am J Respir Cell Mol Biol
American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory Cell and Molecular Biology
The impact of lipotoxicity on the development of lung fibrosis is unclear. Saturated fatty acids, such as palmitic acid (PA), activate endoplasmic reticulum (ER) stress, a cellular stress response associated with the development of idiopathic pulmona
Publikováno v:
Am J Respir Cell Mol Biol
Autor:
Khodr Tello, Rory E. Morty, Susanne Herold, Werner Seeger, Vitalii Kryvenko, Miriam Wessendorf, István Vadász
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Acute respiratory distress syndrome (ARDS) is often associated with elevated levels of CO2 (hypercapnia) and impaired alveolar fluid clearance. Misfolding of the Na,K-ATPase (NKA), a key molecule i...
Publikováno v:
Am J Respir Cell Mol Biol
Obstructive sleep apnea is associated with insulin resistance, lipid dysregulation, and hepatic steatosis and fibrosis in nonalcoholic fatty liver disease (NAFLD). We have previously shown that hepatocyte HIF-1 (hypoxia-inducible factor-1) mediates t
Autor:
Padmesh S. Rajput, Maranatha Ayodele, Peyton L. Nisson, Faizan Anwar, Michael M Gezalian, Shouri Lahiri, Mohammad H. Rashid, Shahed Toossi, Nicklaus A. Sparrow, S. Ananth Karumanchi, Ambart E. Covarrubias, E. Wesley Ely
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Am J Respir Cell Mol Biol
Am J Respir Cell Mol Biol
Mechanical ventilation is a known risk factor for delirium, a cognitive impairment characterized by dysfunction of the frontal cortex and hippocampus. Although IL-6 is upregulated in mechanical ventilation–induced lung injury (VILI) and may contrib
Autor:
Benjamin Grimmer, Wolfgang M. Kuebler
Publikováno v:
Am J Respir Cell Mol Biol
Chronic hypoxia (CH) augments depolarization-induced pulmonary vasoconstriction through superoxide-dependent, Rho kinase–mediated Ca(2+) sensitization. Nicotinamide adenine dinucleotide phosphate oxidase and EGFR (epidermal growth factor receptor)