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Walking down the 'IL': The Newfound Marriage between IL-36 and Chronic Obstructive Pulmonary Disease
Autor:
Jay K. Kolls, Janet E. McCombs
Publikováno v:
Am J Respir Cell Mol Biol
Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory lung disease with high morbidity and mortality. The IL-36 family are proinflammatory cytokines that are known to shape innate immune responses, including those critical to bac
Autor:
Kazuya Tanimura, Toru Nyunoya
Publikováno v:
Am J Respir Cell Mol Biol
American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory Cell and Molecular Biology
A history of chronic cigarette smoking is known to increase risk for acute respiratory distress syndrome (ARDS), but the corresponding risks associated with chronic e-cigarette use are largely unknown. The chromosomal fragile site gene, WWOX, is high
Autor:
Robert H. Brown, Terence R. Flotte, Miguel Sena-Esteves, Allison M. Keeler, Mai K. ElMallah, Lang Xiong, Lorelei Stoica, Michael Kalfopoulos, Kaitlyn Desrochers
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 56:405-408
Autor:
Mathew Suji Eapen, Kielan Darcy McAlinden, Sukhwinder Singh Sohal, Pawan K. Sharma, Wenying Lu
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 63:269-270
Autor:
Anne M. Manicone, Matthew E. Long
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 63:9-10
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 55:368-376
High serotonin levels during pregnancy affect central nervous system development. Whether a commonly used antidepressant such as fluoxetine (a selective serotonin reuptake inhibitor) taken during pregnancy may adversely affect respiratory control in
Autor:
Dominique Rideau, Valérie Amsellem, Aurélien Parpaleix, Laurent Baud, Feng Wan, Marion Delcroix, Barnabas Gellen, Emmanuel Letavernier, Rozenn Quarck, Shariq Abid, Larissa Lipskaia, Amal Houssaini, Daigo Sawaki, Serge Adnot, Geneviève Derumeaux, Gabor Czibik, Elisabeth Marcos, Jean-Luc Dubois-Randé
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 55:337-351
Excessive growth of pulmonary arterial (PA) smooth muscle cells (SMCs) is a major component of PA hypertension (PAH). The calcium-activated neutral cysteine proteases calpains 1 and 2, expressed by PASMCs, contribute to PH but are tightly controlled
Autor:
Yutong Zhao, Vincent Esguerra
Publikováno v:
Am J Respir Cell Mol Biol
It has been increasingly recognized lately that aberrant cellular metabolism plays an important role in the pathogenesis of pulmonary fibrosis. In our previous systemic studies, we found that human lung myofibroblasts undergo glutaminolytic reprogram
Autor:
Jennifer L. Ingram
Publikováno v:
Am J Respir Cell Mol Biol
American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory Cell and Molecular Biology
Thickening of the airway smooth muscle is central to bronchial hyperreactivity. We have shown that the sphingosine analog (R)-2-amino-4-(4-heptyloxyphenyl)-2-methylbutanol (AAL-R) can reverse preestablished airway hyperreactivity in a chronic asthma
Autor:
Vitalii Kryvenko, István Vadász
Publikováno v:
Am J Respir Cell Mol Biol
High CO(2) retention, or hypercapnia, is associated with worse outcomes in patients with chronic pulmonary diseases. Skeletal muscle wasting is also an independent predictor of poor outcomes in patients with acute and chronic pulmonary diseases. Alth