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Autor:
Teja Gregorc, Craig K. Docherty, Afshan Dean, Margaret R. MacLean, Katie Y. Harvey, Margaret Nilsen, Nicholas W. Morrell
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 58:320-330
Rationale: Rats dosed with the vascular endothelial growth factor (VEGF) inhibitor Sugen 5416 (Su), placed in hypoxia then restored to normoxia has become a widely used model of pulmonary arterial hypertension (PAH). The mechanism by which Su exaccer
Autor:
Carol Feghali-Bostwick, Joo Hun Park, Jun Ikari, Myron L. Toews, Yoko Gunji, Joel Michalski, Xiangde Liu, Maha Farid, Nancy A. Schulte, Steve Nogel, Amy Nelson, Hesham Basma, Hermann Tenor, Shunichiro Iwasawa, Stephen I. Rennard, Xingqi Wang
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 49:571-581
Lung fibroblasts are believed to be a major source of vascular endothelial growth factor (VEGF), which supports the survival of lung endothelial cells and modulates the maintenance of the pulmonary microvasculature. VEGF has been related to the patho
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 46:40-47
Stimulation by the ephrin-A1 ligand of the EphA2 receptor increases endothelial permeability. Lung injury increases the expression of EphA2, but the role of EphA2 in such injury is not well understood. To determine whether EphA2 contributes to change
Autor:
Md. Mostafizur Rahman, Alaina J. Ammit, Nowshin N. Rumzhum, Brian G. Oliver, Brijeshkumar S. Patel, Nicole M. Verrills
Publikováno v:
American journal of respiratory cell and molecular biology. 54(6)
Copyright © 2016 by the American Thoracic Society. Theophylline is an old drug experiencing a renaissance owing to its beneficial antiinflammatory effects in chronic respiratory diseases, such as asthma and chronic obstructive pulmonary disease. Mul
Autor:
Jhi Jhu Hwang, Wen Chi Chen, Inn Wen Chong, Yu-Jen Cheng, Po Len Liu, Shah Hwa Chou, Jong Rung Tsai, Yuh-Lien Chen, Feng Yen Lin, Chun Ying Hung, Yung-Hsiang Chen
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 43:530-538
High-mobility group box 1 (HMGB1) is a versatile protein with intranuclear and extracellular functions. It is involved in invasion and metastasis in various human malignancies. However, the role of HMGB1 in non-small cell lung cancer (NSCLC) is uncle
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 39:296-304
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian central nervous system and exerts its actions via both ionotropic (GABA(A)) and metabotropic (GABA(B)) receptors. The GABA(B) receptor is a dimer composed of R1
Autor:
Michel Aubier, Isabelle Mosnier, Martine Grandsaigne, Benoit Feger, Delphine El Mehdi, Jean-Marie Zahm, Laurent Benayoun, Marie-Christine Dombret, Joël Depondt, Marina Pretolani, Anne Druilhe
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 38:276-282
Abnormal epithelial repair to damage participates in airway remodeling in asthma by the paracrine regulation of mesenchymal cell functions. Retinoids control epithelial functions through nuclear retinoic acid receptor (RAR) and retinoid X receptor (R
Autor:
Craig B. Neylon, Glenn Cruse, Malcolm Shepherd, Peter Bradding, S. Mark Duffy, Trudi Harris, Alastair G. Stewart, Christopher E. Brightling, Michael Schuliga
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 37:525-531
Airway smooth muscle cell hyperplasia contributes to airway remodeling and hyperreactivity characteristic of asthma. Changes to potassium channel activity in proliferating human airway smooth muscle (HASM) cells have been described, but no regulatory
Autor:
Michael Schuliga, Shenna Y. Langenbach, Trudi Harris, Christine R. Keenan, Asres Berhan, Simon G. Royce, Alastair G. Stewart
Publikováno v:
American journal of respiratory cell and molecular biology. 54(2)
During asthma exacerbation, plasma circulating coagulant factor X (FX) enters the inflamed airways and is activated (FXa). FXa may have an important role in asthma, being involved in thrombin activation and an agonist of protease-activated receptor-1
Autor:
Christine Stichnote, Susanne Haag, Sonja Matthiesen, Amit Bahulayan, Susanne Kempkens, Margarita Fuhrmann, Kurt Racké, Uwe R. Juergens
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 35:621-627
Airway remodeling is a structural alteration associated with chronic inflammatory and obstructive airway diseases, wherein fibroblasts are crucially involved. The present study investigates whether lung fibroblast proliferation is influenced by musca