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pro vyhledávání: ''
Autor:
Denielli da Silva Goncalves Bos, Robert Szulcek, Frances S. de Man, Xiaoke Pan, Maria Catalina Gomez-Puerto, Willem J. van der Laarse, Ingrid Schalij, Anton Vonk Noordegraaf, Harm Jan Bogaard, Roy E. J. Schiepers, Eva L. Peters, Stine Andersen, Asger Andersen, Marie-José Goumans, Xiao-Qing Sun, Julie Birkmose Axelsen, Kondababu Kurakula
Publikováno v:
Sun, X-Q, Peters, E L, Schalij, I, Axelsen, J B, Andersen, S, Kurakula, K, Gomez-Puerto, M C, Szulcek, R, Pan, X, da Silva Goncalves Bos, D, Schiepers, R E, Andersen, A, Goumans, M-J, Vonk Noordegraaf, A, van der Laarse, W J, de Man, F S & Bogaard, H J 2021, ' Increased MAO-A Activity Promotes Progression of Pulmonary Arterial Hypertension ', American Journal of Respiratory Cell and Molecular Biology (Online), vol. 64, no. 3, pp. 331-343 . https://doi.org/10.1165/rcmb.2020-0105OC
American Journal of Respiratory Cell and Molecular Biology, 64(3), 331-343. American Thoracic Society
Sun, X-Q, Peters, E L, Schalij, I, Axelsen, J B, Andersen, S, Kurakula, K, Gomez-Puerto, M C, Szulcek, R, Pan, X, da Silva Goncalves Bos, D, Schiepers, R E J, Andersen, A, Goumans, M-J, Noordegraaf, A V, van der Laarse, W J, de Man, F S & Bogaard, H J 2021, ' Increased MAO-A activity promotes progression of pulmonary arterial hypertension ', American Journal of Respiratory Cell and Molecular Biology, vol. 64, no. 3, pp. 331-343 . https://doi.org/10.1165/rcmb.2020-0105OC, https://doi.org/10.1165/rcmb.2020-0105OC
American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory Cell and Molecular Biology, 64(3), 331-343. AMER THORACIC SOC
American Journal of Respiratory Cell and Molecular Biology, 64(3), 331-343. American Thoracic Society
Sun, X-Q, Peters, E L, Schalij, I, Axelsen, J B, Andersen, S, Kurakula, K, Gomez-Puerto, M C, Szulcek, R, Pan, X, da Silva Goncalves Bos, D, Schiepers, R E J, Andersen, A, Goumans, M-J, Noordegraaf, A V, van der Laarse, W J, de Man, F S & Bogaard, H J 2021, ' Increased MAO-A activity promotes progression of pulmonary arterial hypertension ', American Journal of Respiratory Cell and Molecular Biology, vol. 64, no. 3, pp. 331-343 . https://doi.org/10.1165/rcmb.2020-0105OC, https://doi.org/10.1165/rcmb.2020-0105OC
American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory Cell and Molecular Biology, 64(3), 331-343. AMER THORACIC SOC
Monoamine oxidases (MAOs), a class of enzymes bound to the outer mitochondrial membrane, are important sources of reactive oxygen species. Increased MAO-A activity in endothelial cells and cardiomyocytes contributes to vascular dysfunction and progre
Autor:
Souheil El-Chemaly, Ehab A. Ayaub, Konstantin Tsoyi, Kevin Xiong, Yuanyuan Shi, Raju V. V. Tatituri, Sarah G. Chu, Bonna Ith, Fong-Fu Hsu, Xiaoliang Liang, Derek E. Byers, Ivan O. Rosas, Julian A. Villalba, Edy Y. Kim
Publikováno v:
Am J Respir Cell Mol Biol
American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory Cell and Molecular Biology
The impact of lipotoxicity on the development of lung fibrosis is unclear. Saturated fatty acids, such as palmitic acid (PA), activate endoplasmic reticulum (ER) stress, a cellular stress response associated with the development of idiopathic pulmona
Autor:
Larissa A. Shimoda, Eva Nozik-Grayck
Publikováno v:
Am J Respir Cell Mol Biol
Pulmonary hypertension (PH) and right ventricular (RV) hypertrophy frequently develop in patients with hypoxic lung disease. Chronic alveolar hypoxia (CH) promotes sustained pulmonary vasoconstriction and pulmonary artery (PA) remodeling by acting on
Autor:
Teja Gregorc, Craig K. Docherty, Afshan Dean, Margaret R. MacLean, Katie Y. Harvey, Margaret Nilsen, Nicholas W. Morrell
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 58:320-330
Rationale: Rats dosed with the vascular endothelial growth factor (VEGF) inhibitor Sugen 5416 (Su), placed in hypoxia then restored to normoxia has become a widely used model of pulmonary arterial hypertension (PAH). The mechanism by which Su exaccer
Autor:
Kazuya Tanimura, Toru Nyunoya
Publikováno v:
Am J Respir Cell Mol Biol
American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory Cell and Molecular Biology
A history of chronic cigarette smoking is known to increase risk for acute respiratory distress syndrome (ARDS), but the corresponding risks associated with chronic e-cigarette use are largely unknown. The chromosomal fragile site gene, WWOX, is high
Autor:
Mathew Suji Eapen, Kielan Darcy McAlinden, Sukhwinder Singh Sohal, Pawan K. Sharma, Wenying Lu
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 63:269-270
Autor:
Juan Pablo de Rivero Vaccari, W. Dalton Dietrich, Shihua Luo, Fredrick Dapaah-Siakwan, Karen Young, Matthew R. Duncan, Merline Benny, Robert W. Keane, Nadine Kerr, Keyur Donda, Shu Wu, Ronald Zambrano
Publikováno v:
American journal of respiratory cell and molecular biology. 61(3)
Hyperoxia plays a key role in the development of bronchopulmonary dysplasia (BPD), a chronic lung disease of preterm infants. Infants with BPD often have brain injury that leads to long-term neurodevelopmental impairment, but the underlying mechanism
Autor:
Stephen M. Black, Sanjeev A. Datar, Eric G. Johnson, Gary W. Raff, Terry Zhu, Ting Wang, Csaba Galambos, Qing Lu, Brian D. Goudy, Catherine Morris, Jeffrey R. Fineman, Xutong Sun, Jason B. Boehme, Rebecca J Kameny, Emin Maltepe, Samuel R. Chiacchia
Publikováno v:
Am J Respir Cell Mol Biol
American journal of respiratory cell and molecular biology, vol 60, iss 5
American journal of respiratory cell and molecular biology, vol 60, iss 5
The natural history of pulmonary vascular disease associated with congenital heart disease (CHD) depends on associated hemodynamics. Patients exposed to increased pulmonary blood flow (PBF) and pulmonary arterial pressure (PAP) develop pulmonary vasc
Autor:
Leslie Spikes, Pranjali Dalvi, Julie Allen, Navneet K. Dhillon, Marion Gillcrist, Jamison Montes de Oca, Himanshu Sharma, Vijayalaxmi Gupta, Amy O'Brien-Ladner
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 55:201-212
Human immunodeficiency virus (HIV)-related pulmonary arterial hypertension has been found to be more prevalent in intravenous drug users. Our earlier cell-culture findings reported down-regulation of bone morphogenetic protein receptors (BMPRs) in co
Autor:
Oliver H. Wittekindt, Veronika Eva Winkelmann, Peter Braubach, Paul Dietl, Hanna Schmidt, Manfred Frick, Felix Kielgast, Kristin Thompson
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 54:707-717
The lung epithelium constitutes a selective barrier that separates the airways from the aqueous interstitial compartment. Regulated barrier function controls water and ion transport across the epithelium and is essential for maintaining lung function