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pro vyhledávání: ''
Autor:
Denielli da Silva Goncalves Bos, Robert Szulcek, Frances S. de Man, Xiaoke Pan, Maria Catalina Gomez-Puerto, Willem J. van der Laarse, Ingrid Schalij, Anton Vonk Noordegraaf, Harm Jan Bogaard, Roy E. J. Schiepers, Eva L. Peters, Stine Andersen, Asger Andersen, Marie-José Goumans, Xiao-Qing Sun, Julie Birkmose Axelsen, Kondababu Kurakula
Publikováno v:
Sun, X-Q, Peters, E L, Schalij, I, Axelsen, J B, Andersen, S, Kurakula, K, Gomez-Puerto, M C, Szulcek, R, Pan, X, da Silva Goncalves Bos, D, Schiepers, R E, Andersen, A, Goumans, M-J, Vonk Noordegraaf, A, van der Laarse, W J, de Man, F S & Bogaard, H J 2021, ' Increased MAO-A Activity Promotes Progression of Pulmonary Arterial Hypertension ', American Journal of Respiratory Cell and Molecular Biology (Online), vol. 64, no. 3, pp. 331-343 . https://doi.org/10.1165/rcmb.2020-0105OC
American Journal of Respiratory Cell and Molecular Biology, 64(3), 331-343. American Thoracic Society
Sun, X-Q, Peters, E L, Schalij, I, Axelsen, J B, Andersen, S, Kurakula, K, Gomez-Puerto, M C, Szulcek, R, Pan, X, da Silva Goncalves Bos, D, Schiepers, R E J, Andersen, A, Goumans, M-J, Noordegraaf, A V, van der Laarse, W J, de Man, F S & Bogaard, H J 2021, ' Increased MAO-A activity promotes progression of pulmonary arterial hypertension ', American Journal of Respiratory Cell and Molecular Biology, vol. 64, no. 3, pp. 331-343 . https://doi.org/10.1165/rcmb.2020-0105OC, https://doi.org/10.1165/rcmb.2020-0105OC
American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory Cell and Molecular Biology, 64(3), 331-343. AMER THORACIC SOC
American Journal of Respiratory Cell and Molecular Biology, 64(3), 331-343. American Thoracic Society
Sun, X-Q, Peters, E L, Schalij, I, Axelsen, J B, Andersen, S, Kurakula, K, Gomez-Puerto, M C, Szulcek, R, Pan, X, da Silva Goncalves Bos, D, Schiepers, R E J, Andersen, A, Goumans, M-J, Noordegraaf, A V, van der Laarse, W J, de Man, F S & Bogaard, H J 2021, ' Increased MAO-A activity promotes progression of pulmonary arterial hypertension ', American Journal of Respiratory Cell and Molecular Biology, vol. 64, no. 3, pp. 331-343 . https://doi.org/10.1165/rcmb.2020-0105OC, https://doi.org/10.1165/rcmb.2020-0105OC
American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory Cell and Molecular Biology, 64(3), 331-343. AMER THORACIC SOC
Monoamine oxidases (MAOs), a class of enzymes bound to the outer mitochondrial membrane, are important sources of reactive oxygen species. Increased MAO-A activity in endothelial cells and cardiomyocytes contributes to vascular dysfunction and progre
Autor:
Souheil El-Chemaly, Ehab A. Ayaub, Konstantin Tsoyi, Kevin Xiong, Yuanyuan Shi, Raju V. V. Tatituri, Sarah G. Chu, Bonna Ith, Fong-Fu Hsu, Xiaoliang Liang, Derek E. Byers, Ivan O. Rosas, Julian A. Villalba, Edy Y. Kim
Publikováno v:
Am J Respir Cell Mol Biol
American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory Cell and Molecular Biology
The impact of lipotoxicity on the development of lung fibrosis is unclear. Saturated fatty acids, such as palmitic acid (PA), activate endoplasmic reticulum (ER) stress, a cellular stress response associated with the development of idiopathic pulmona
Publikováno v:
Am J Respir Cell Mol Biol
Autor:
Padmesh S. Rajput, Maranatha Ayodele, Peyton L. Nisson, Faizan Anwar, Michael M Gezalian, Shouri Lahiri, Mohammad H. Rashid, Shahed Toossi, Nicklaus A. Sparrow, S. Ananth Karumanchi, Ambart E. Covarrubias, E. Wesley Ely
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Am J Respir Cell Mol Biol
Am J Respir Cell Mol Biol
Mechanical ventilation is a known risk factor for delirium, a cognitive impairment characterized by dysfunction of the frontal cortex and hippocampus. Although IL-6 is upregulated in mechanical ventilation–induced lung injury (VILI) and may contrib
Autor:
Davide Amidani, Mercedes Echaide, Jesús Pérez-Gil, Fabrizio Salomone, Rafael Bragado, Shivani Shankar-Aguilera, Daniele De Luca, Chiara Autilio
Publikováno v:
American journal of respiratory cell and molecular biology. 63(3)
No in vivo data are available regarding the effect of meconium on human surfactant in the early stages of severe meconium aspiration syndrome (MAS). In the present study, we sought to characterize ...
Autor:
Andrea L. Frump, Mona Selej, Bakhtiyor Yakubov, Marjorie Albrecht, Irina Petrache, Jordan A. Wood, Tim Lahm
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 59:114-126
17β-Estradiol (E2) attenuates hypoxia-induced pulmonary hypertension (HPH) through estrogen receptor (ER)-dependent effects, including inhibition of hypoxia-induced endothelial cell proliferation; however, the mechanisms responsible for this remain
Autor:
Teja Gregorc, Craig K. Docherty, Afshan Dean, Margaret R. MacLean, Katie Y. Harvey, Margaret Nilsen, Nicholas W. Morrell
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 58:320-330
Rationale: Rats dosed with the vascular endothelial growth factor (VEGF) inhibitor Sugen 5416 (Su), placed in hypoxia then restored to normoxia has become a widely used model of pulmonary arterial hypertension (PAH). The mechanism by which Su exaccer
Walking down the 'IL': The Newfound Marriage between IL-36 and Chronic Obstructive Pulmonary Disease
Autor:
Jay K. Kolls, Janet E. McCombs
Publikováno v:
Am J Respir Cell Mol Biol
Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory lung disease with high morbidity and mortality. The IL-36 family are proinflammatory cytokines that are known to shape innate immune responses, including those critical to bac
Autor:
Kazuya Tanimura, Toru Nyunoya
Publikováno v:
Am J Respir Cell Mol Biol
American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory Cell and Molecular Biology
A history of chronic cigarette smoking is known to increase risk for acute respiratory distress syndrome (ARDS), but the corresponding risks associated with chronic e-cigarette use are largely unknown. The chromosomal fragile site gene, WWOX, is high
Autor:
Jennifer L. Ingram
Publikováno v:
Am J Respir Cell Mol Biol
American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory Cell and Molecular Biology
Thickening of the airway smooth muscle is central to bronchial hyperreactivity. We have shown that the sphingosine analog (R)-2-amino-4-(4-heptyloxyphenyl)-2-methylbutanol (AAL-R) can reverse preestablished airway hyperreactivity in a chronic asthma