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Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 68:13-22
Endothelial colony-forming cells (ECFCs) are vascular resident and circulating endothelial cell subtypes with potent angiogenic capacity, a hierarchy of single-cell clonogenic potentials, and the ability to participate in
Autor:
Belinda J. Hernandez, Margo P. Cain, Anne M. Lynch, Jose R. Flores, Michael J. Tuvim, Burton F. Dickey, Jichao Chen
Publikováno v:
Am J Respir Cell Mol Biol
The lung epithelium forms the first barrier against respiratory pathogens and noxious chemicals; however, little is known about how more than 90% of this barrier, made of AT1 (alveolar type 1) cells, responds to injury. Using the Sendai virus to mode
Autor:
Jean-Paul Courneya, Rita Fishelevich, Irina G. Luzina, Violeta Rus, Sergei P. Atamas, Brian Hampton, Alexander V. Misharin, Nevins W. Todd, Virginia Lockatell, Tudor C. Badea, Horea Rus
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 66:146-157
Some previous studies in tissue fibrosis have suggested a profibrotic contribution from elevated expression of a protein termed either Regulator of Cell Cycle (RGCC) or Response Gene to Complement 32 Protein (RGC-32). Our analysis of public gene expr
Autor:
Robert E. Hynds, Jessica C. Orr
Publikováno v:
Am J Respir Cell Mol Biol
Advances in stem cell biology and the understanding of factors that determine lung stem cell self-renewal have enabled long-term in vitro culture of human lung cells derived from airway basal and alveolar type II cells. Improved capability to expand
Autor:
Guoqing Qian, Ann Jeffers, Shuzi Owens, Prashant Chauhan, Mitsuo Ikebe, Wenyi Qin, Torry A. Tucker, Steven Idell, Satoshi Komatsu, Xia Guo
Publikováno v:
Am J Respir Cell Mol Biol
Pleural organization may occur after empyema or complicated parapneumonic effusion and can result in restrictive lung disease with pleural fibrosis (PF). Pleural mesothelial cells (PMCs) may contribute to PF through acquisition of a profibrotic pheno
Autor:
Gustavo Nino, Elizabeth Chorvinsky, Dinesh K. Pillai, Karima Abutaleb, Jyoti K. Jaiswal, Jose L. Gomez, Maria Arroyo, Girija Thiruvengadam, Maria J. Gutierrez, Kyle Salka
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Autor:
Joo Heon Yoon, Seol Ah Yoon, Ji Min Song, Sang-Nam Lee, Augustine M.K. Choi, Hyung Chul Kim, Ji-Suk Ahn, Su Jin Kim
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 64:247-259
In allergic airway diseases, intermediate progenitor cells (IPCs) increase in number in the surface epithelium. IPCs arise from basal cells, the origin of hallmark pathological changes, including goblet cell hyperplasia and mucus hypersecretion. Thus
Autor:
Khan, Sadiya S.
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Endothelial dysfunction is implicated in the thrombotic events reported in patients with coronavirus disease (COVID-19), but the underlying molecular mechanisms are unknown. Circulating levels of the coagulation cascade activator PAI-1 are substantia
Autor:
Mario Boehm, Norbert Weissmann, Danny Jonigk, Friedrich Grimminger, Astrid Weiss, Beate Christiane Schlueter, Clemens Ruppert, Ralph T. Schermuly, Baktybek Kojonazarov, Werner Seeger, Dinesh Yerabolu, Andreas Günther, Hossein Ardeschir Ghofrani
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
In pulmonary arterial hypertension (PAH), progressive structural remodeling accounts for the pulmonary vasculopathy including the obliteration of the lung vasculature that causes an increase in vascular resistance and mean blood pressure in the pulmo
Autor:
Steven F. Ziegler, Sina A. Gharib, Ryan C. Murphy, Jason S. Debley, Kaitlyn A Barrow, William A. Altemeier, Jessica A. Hamerman, Ying Lai, Adam Lacy-Hulbert, Adrian M. Piliponsky, Teal S. Hallstrand
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology