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Autor:
Mario Boehm, Norbert Weissmann, Danny Jonigk, Friedrich Grimminger, Astrid Weiss, Beate Christiane Schlueter, Clemens Ruppert, Ralph T. Schermuly, Baktybek Kojonazarov, Werner Seeger, Dinesh Yerabolu, Andreas Günther, Hossein Ardeschir Ghofrani
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
In pulmonary arterial hypertension (PAH), progressive structural remodeling accounts for the pulmonary vasculopathy including the obliteration of the lung vasculature that causes an increase in vascular resistance and mean blood pressure in the pulmo
Autor:
Zaid Shakir, Steven M. Dudek, C M Aldaz, A. Moshensky, Viswanathan Natarajan, Jeffrey R. Jacobson, Weiguo Chen, Lorraine B. Ware, Sunit Singla, Raheel Khan, Laura E. Crotty Alexander, Roberto Machado, Zhenguo Zeng
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 64:89-99
A history of chronic cigarette smoking is known to increase risk for acute respiratory distress syndrome (ARDS), but the corresponding risks associated with chronic e-cigarette use are largely unkn...
Autor:
Keisuke Tsukioka, Masaaki Arakawa, Takashi Hasegawa, Hiroyuki Takeuchi, Akira Saito, Satoshi Watanabe, Hiroshi Ueno, Yosuke Kimura, Masachika Hayashi, Toshiyuki Koya, Toshiaki Kikuchi
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 63:57-66
It is well known that the prevalence of asthma is higher in athletes, including Olympic athletes, than in the general population. In this study, we analyzed the mechanism of exercise-induced bronchoconstriction by using animal models of athlete asthm
Autor:
Abdul K. Parchur, Brianna Entringer, Teresa Michalkiewicz, Girija G. Konduri, Ru-Jeng Teng, Amit Joshi, Ujala Rana, Emily Callan
Publikováno v:
Am J Respir Cell Mol Biol
Decreased angiogenesis contributes to persistent pulmonary hypertension of the newborn (PPHN); mechanisms remain unclear. AMPK (5′AMP activated protein kinase) is a key regulator of cell metabolism. We investigated the hypothesis that a decrease in
Autor:
Tao Sun, Jay K. Kolls, Wei Chen, Kong Chen, Annabel A. Ferguson, Joseph M. Pilewski, Yale Jiang, Zhe Sun
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 61:643-652
Ivacaftor is a drug that was recently approved by the U.S. Food and Drug Administration for the treatment of patients with cystic fibrosis (CF) and at least one copy of the G511D mutation in the CFTR (CF transmembrane conductance regulator) gene. The
Autor:
Angeles Fernandez-Gonzalez, Nicolas Christodoulou, Laura E. Fredenburgh, Helen Christou, Paul B. Dieffenbach, Hannes Hudalla, Gareth R. Willis, Evgenia J. Filatava, Zoe Michael, Robert S. Stearman, Mark W. Geraci, Stella Kourembanas
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Inflammation and vascular smooth muscle cell (VSMC) phenotypic switching are causally linked to pulmonary arterial hypertension (PAH) pathogenesis. Carbonic anhydrase inhibition induces mild metabolic acidosis and exerts protective effects in hypoxic
Autor:
Alexander V. Misharin, Hiam Abdala-Valencia, Hanh Chi Do Umehara, William J Muller, Kishore R Anekalla, Jairo Chavez, Benjamin D. Singer, Taylor Heald-Sargent, Yuliya Politanska, Clarissa M. Koch, Andrew D. Prigge, Nikolay S. Markov, Grant R Hahn, Karen M. Ridge, Avani Shukla, L. Nelson Sanchez-Pinto, Leah Setar, Bria M. Coates
Publikováno v:
American journal of respiratory cell and molecular biology. 66(2)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than 180 million people since the onset of the global pandemic. Despite similar viral load and infectivity rates between children and adults, children rarely develop sever
Autor:
Bharati Prasad, Susmita Chowdhuri
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 63:410-412
Autor:
Margaret Rosenfeld, Mary J. Emond, Felicia K. Nguyen, Thomas R. Hawn, Andrew D. Graustein, Lara L. Joudeh, William R. Berrington, Michael J. Bamshad, Kati J. Buckingham, Ronald L. Gibson
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Cystic fibrosis (CF) is characterized by chronic airway infection, inflammation, and tissue damage that lead to progressive respiratory failure. NLRP3 and NLRC4 are cytoplasmic pattern recognition receptors that activate the inflammasome, initiating
Autor:
Michael J Norris, Wenming Duan, Yuchen Cen, Yi-Chieh Tseng, Jason T. Maynes, Andrea Granados, Manpreet Malhi, Jonathan B. Gubbay, Hong Ouyang, Theo J. Moraes
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 59:733-744
Respiratory syncytial virus (RSV) is a leading cause of mortality in infants and young children. Despite the RSV disease burden, no vaccine is available, and treatment remains nonspecific. New drug candidates are needed to combat RSV. Toward this goa