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Autor:
Vlahos, Ross
Publikováno v:
Am J Respir Cell Mol Biol
American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory Cell and Molecular Biology
Sphingomyelin synthase is responsible for the production of sphingomyelin (SGM), the second most abundant phospholipid in mammalian plasma, from ceramide, a major sphingolipid. Knowledge of the effects of cigarette smoke on SGM production is limited.
Autor:
Scott R. Tyler, Nam Soo Joo, Hyung Ju Cho, Jordy J. Hsiao, Michael E. Wright, T. Idil Apak Evans, Weiliang Xie, Yulong Zhang, Ziying Yan, Nicholas W. Keiser, John F. Engelhardt, Jeffrey J. Wine
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 54:469-481
Defects in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel lead to viscous secretions from submucosal glands that cannot be properly hydrated and cleared by beating cilia in cystic fibrosis (CF) airways. The mechanisms
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 54:128-135
Tachyphylaxis of the β2-adrenergic receptor limits the efficacy of bronchodilatory β2-agonists in respiratory disease. Cellular studies in airway smooth muscle (ASM) have shown that inflammatory mediators and infectious stimuli reduce β2-adrenergi
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 49:672-679
Cystic fibrosis transmembrane conductance regulator (CFTR) activity is essential for the maintenance of airway surface liquid depth, and therefore mucociliary clearance. Reactive oxygen species, increased during inflammatory airway diseases, alter CF
Autor:
Philip R. Cooper, Kirk M. Druey, Reynold A. Panettieri, Richard Edwards, Gautam Damera, Nariman Balenga, Christopher E. Brightling, Zhao Yang
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 46:823-832
Severe asthma is associated with fixed airway obstruction attributable to inflammation, copious luminal mucus, and increased airway smooth muscle (ASM) mass. Paradoxically, studies demonstrated that the hypertrophic and hyperplastic ASM characteristi
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 45:1069-1074
Bitter taste receptors (TAS2Rs) were shown to be expressed in human airway smooth muscle (ASM). They couple to specialized [Ca(2+)](i) release, leading to membrane hyperpolarization, the relaxation of ASM, and marked bronchodilation. TAS2Rs are G-pro
Autor:
Tsuyoshi Tanabe, Bruce K. Rubin, Yoshitaka Yamazaki, Soichiro Kanoh, Kenji Tsushima, Keishi Kubo
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 45:1075-1083
IL-13 is a T-helper class 2 cytokine that induces goblet cell hyperplasia and mucus production in airway epithelial cells. Because macrolide antibiotics are known to have immunomodulatory and mucoregulatory properties, the aim of this study was to ex
Autor:
Hamid Band, Art J. Heires, Myron L. Toews, Nancy A. Schulte, Puttappa R. Dodmane, Debra J. Romberger
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 45:882-888
A subset of workers in swine confinement facilities develops chronic respiratory disease. An aqueous extract of dust from these facilities (hogbarn dust extract [HDE]) induces IL-6 and IL-8 release and several other responses in isolated airway epith
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 44:222-229
Maternal smoking during pregnancy increases the risk of respiratory disease in offspring, but surprisingly little is known about the underlying mechanisms. Nicotinic acetylcholine receptors (nAChRs) expressed in bronchial epithelial cells (BECs) medi
Autor:
Lyn M. Moir, Helen K. Reddel, Curtis Kuo, Qi Ge, Janette K. Burgess, Judith L. Black, Nicholas J. C. King, Brent E. McParland, Thomas Trian, Brian G. Oliver
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology, 43(2), 227-233. AMER THORACIC SOC
Rhinovirus (RV) infections are the major cause of asthma exacerbations in children and adults. Under normal circumstances, asthmatic airway obstruction improves spontaneously or characteristically briskly in response to inhaled beta(2)-adrenergic rec