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Autor:
Ma'en Obeidat, Gilles Vanderstocken, Corry-Anke Brandsma, John A. Hassell, Yohan Bossé, Pamela Shen, Martin R. Stämpfli, Anna Dvorkin-Gheva
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 58:727-735
Cigarette smoking is the main risk factor for chronic obstructive pulmonary disease, and to date, existing pharmacologic interventions have been ineffective at controlling inflammatory processes associated with the disease. To address this issue, we
Autor:
Sharon Wannberg, James B. Rottman, Sabine S. Escobar, Joel Tocker, Daniela Metz, Michael R. Comeau, Deanna Mohn, Kira Misura, Alison L. Budelsky, Anh Leith, Erika Rickel, Lori Siegel, John K. Sullivan, Cynthia R. Willis
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 53:810-821
Asthma is a heterogeneous disease characterized by airway inflammation and hyperreactivity. IL-17 receptor A (IL-17RA) is a shared receptor subunit required for activity of IL-17 family cytokines, including IL-17A and IL-25. IL-17A and IL-25 induce d
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 51:370-379
Tobacco smokers often display increased airway hyperreactivity (AHR) when faced with bacterial infections. The present study uses a murine organ-culture model to dissect the mechanisms involved in this exaggerated smooth muscle response. Nicotine sim
Autor:
Narayanam V. Rao, Shuo Zheng, W. Michael Foster, Judith A. Voynow, Kathryn L. Griffin, Thomas P. Kennedy, Apparao B. Kummarapurugu, Bernard M. Fischer
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 50:684-689
Neutrophil elastase (NE) is a major inflammatory mediator in cystic fibrosis (CF) that is a robust predictor of lung disease progression. NE directly causes airway injury via protease activity, and propagates persistent neutrophilic inflammation by u
Autor:
Hong Yong Peh, Choon Nam Ong, Yong-Jiang Xu, Chang Cheng, Fengguo Xu, W.S. Fred Wong, Steven R. Tannenbaum, Wanxing Eugene Ho
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 48:204-211
Metabolomics refers to the comprehensive analysis of metabolites in biological systems, and has been employed to study patients with asthma based on their urinary metabolite profile. We hypothesize that airway allergic asthma would affect metabolism
Autor:
Olga Ousova, Patrick Berger, Alain-Pierre Gadeau, Heike Wulff, Peter Bradding, Hugues Begueret, Gabrielle Carvalho, Pierre Olivier Girodet, Annaig Ozier, Roger Marthan, Olga Ilina
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory Cell and Molecular Biology, American Thoracic Society, 2013, 48 (2), pp.212-219. ⟨10.1165/rcmb.2012-0103OC⟩
American Journal of Respiratory Cell and Molecular Biology, American Thoracic Society, 2013, 48 (2), pp.212-219. ⟨10.1165/rcmb.2012-0103OC⟩
Key features of asthma include bronchial hyperresponsiveness (BHR), eosinophilic airway inflammation, and bronchial remodeling, characterized by subepithelial collagen deposition, airway fibrosis, and increased bronchial smooth muscle (BSM) mass. The
Autor:
Ulrike Raap, Bert Verbinnen, Jan Ceuppens, Isabelle Meyts, Greet Hens, Bart M. Vanaudenaerde, Peter Hellings, Dominique Bullens, Pascal Cadot, Jeroen Vanoirbeek, Ina Callebaut, Benoit Nemery
Publikováno v:
American journal of respiratory cell and molecular biology, 44(4), 517-523. American Thoracic Society
Although the concept of "global airway allergy" has become widely accepted during recent years, nasobronchial interaction and its mechanisms remain incompletely understood. The experimental study of the effect of nasal allergen deposition on lower ai
Autor:
Balaram Ghosh, Lokesh Makhija, Ulaganathan Mabalirajan, Amit Sharma, Tanveer Ahmad, Jyotirmoi Aich, Anurag Agrawal
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 44:531-539
Altered arginine metabolism, the uncoupling of nitric oxide synthase (NOS) by asymmetric dimethyl-arginine (ADMA), increased oxo-nitrosative stress, and cellular injury were reported in airway epithelial cells in asthma. Statins improve vascular endo
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 42:243-249
We have reported that moderate-intensity aerobic exercise training attenuates airway inflammation in mice sensitized/challenged with ovalbumin (OVA). The current study determined the effects of repeated bouts of aerobic exercise at a moderate intensi
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 40:83-89
Previous studies have suggested that the asthmatic responses of airway inflammation, remodeling, and hyperresponsiveness (AHR) are interrelated; in this study, we used exercise to examine the nature of this interrelationship. Mice were sensitized and