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Autor:
Mario Boehm, Norbert Weissmann, Danny Jonigk, Friedrich Grimminger, Astrid Weiss, Beate Christiane Schlueter, Clemens Ruppert, Ralph T. Schermuly, Baktybek Kojonazarov, Werner Seeger, Dinesh Yerabolu, Andreas Günther, Hossein Ardeschir Ghofrani
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
In pulmonary arterial hypertension (PAH), progressive structural remodeling accounts for the pulmonary vasculopathy including the obliteration of the lung vasculature that causes an increase in vascular resistance and mean blood pressure in the pulmo
Autor:
Zaid Shakir, Steven M. Dudek, C M Aldaz, A. Moshensky, Viswanathan Natarajan, Jeffrey R. Jacobson, Weiguo Chen, Lorraine B. Ware, Sunit Singla, Raheel Khan, Laura E. Crotty Alexander, Roberto Machado, Zhenguo Zeng
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 64:89-99
A history of chronic cigarette smoking is known to increase risk for acute respiratory distress syndrome (ARDS), but the corresponding risks associated with chronic e-cigarette use are largely unkn...
Autor:
Abdul K. Parchur, Brianna Entringer, Teresa Michalkiewicz, Girija G. Konduri, Ru-Jeng Teng, Amit Joshi, Ujala Rana, Emily Callan
Publikováno v:
Am J Respir Cell Mol Biol
Decreased angiogenesis contributes to persistent pulmonary hypertension of the newborn (PPHN); mechanisms remain unclear. AMPK (5′AMP activated protein kinase) is a key regulator of cell metabolism. We investigated the hypothesis that a decrease in
Autor:
Angeles Fernandez-Gonzalez, Nicolas Christodoulou, Laura E. Fredenburgh, Helen Christou, Paul B. Dieffenbach, Hannes Hudalla, Gareth R. Willis, Evgenia J. Filatava, Zoe Michael, Robert S. Stearman, Mark W. Geraci, Stella Kourembanas
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Inflammation and vascular smooth muscle cell (VSMC) phenotypic switching are causally linked to pulmonary arterial hypertension (PAH) pathogenesis. Carbonic anhydrase inhibition induces mild metabolic acidosis and exerts protective effects in hypoxic
Autor:
Bradley W. Richmond, Marshall Guo, John T. Benjamin, Rui-Hong Du, Linda A. Gleaves, Timothy S. Blackwell, Riet van der Meer, Vasiliy V. Polosukhin, Austin McKissack, Dong-Sheng Cheng, Wei Han, Yongqin Zhang
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 58:736-744
Loss of secretory IgA is common in the small airways of patients with chronic obstructive pulmonary disease and may contribute to disease pathogenesis. Using mice that lack secretory IgA in the airways due to genetic deficiency of polymeric Ig recept
Autor:
Deanna Siow, Jeffrey D. Ritzenthaler, Jesse Roman, Gavin E. Arteel, Edilson Torres-Gonzales, Lauren G. Poole, Nikole L. Warner, James P. Luyendyk, Veronica L. Massey
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 57:315-323
Chronic alcohol exposure is a clinically important risk factor for the development of acute respiratory distress syndrome, the most severe form of acute lung injury (ALI). However, the mechanisms by which alcohol sensitizes the lung to development of
Autor:
Kazuya Tanimura, Toru Nyunoya
Publikováno v:
Am J Respir Cell Mol Biol
American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory Cell and Molecular Biology
A history of chronic cigarette smoking is known to increase risk for acute respiratory distress syndrome (ARDS), but the corresponding risks associated with chronic e-cigarette use are largely unknown. The chromosomal fragile site gene, WWOX, is high
Autor:
Barbara Bacci, Kenneth J. Snibson, Chrishan S. Samuel, Peter Bradding, Cameron J. Nowell, Wayne G. Kimpton, Katy M. Roach, Emmanuel Koumoundouros, Jade Jaffar, Louise Organ, Glen P. Westall
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 56:539-550
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease of increasing prevalence marked by poor prognosis and limited treatment options. Ca2+-activated KCa3.1 potassium channels have been shown to play a key role in the aberrant activat
Autor:
Kelly Q. Schoenfelt, Katherine B. Hisert, B. Grogan, J. Launspach, Gordon Cooke, Charles G. Gallagher, Seamas C. Donnelly, Lev Becker, Pradeep K. Singh, Michael J. Welsh, Edward F. McKone
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 54:594-597
Autor:
Anick Langlois, Kim Santerre, David Marsolais, Ynuk Bossé, Audrey Lee-Gosselin, Laetitia J A Lai, Jean-François Lauzon-Joset, Elyse Y. Bissonnette
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 53:276-284
In allergic asthma, homeostatic pathways are dysregulated, which leads to an immune response toward normally innocuous antigens. The CD200-CD200 receptor pathway is a central regulator of inflammation, and CD200 expression was recently found to be do