Zobrazeno 1 - 10
of 36
pro vyhledávání: '"11"'
Autor:
Thomas J. Hames, Michael J. Day, Gavin I. Welsh, Yan Qiu, David O. Bates, Shaney L Barratt, Toby M. Maher, Khadija Ourradi, Ann B. Millar, Caroline Jarrett, Thomas Blythe, Chris J. Scotton, Golda Shelley-Fraser, Sebastian Oltean, Steve J Harper
Publikováno v:
American journal of respiratory and critical care medicine. 196(4)
RATIONALE: Fibrosis after lung injury is related to poor outcome, and idiopathic pulmonary fibrosis (IPF) can be regarded as an exemplar. Vascular endothelial growth factor (VEGF)-A has been implicated in this context, but there are conflicting repor
Autor:
Jae Sung Yi, Hojin Lee, Argyrios Tzouvelekis, Jose D. Herazo-Maya, Rong Wang, Nikolaos Xylourgidis, Yi Zhang, Patty J. Lee, Tony Woolard, Vassilis Aidinis, Robert J. Homer, Guoying Yu, Naftali Kaminski, Erica L. Herzog, Christian L. Lino Cardenas, Farida Ahangari, Koji Sakamoto, Anton M. Bennett, Giuseppe DeIuliis
Publikováno v:
American Journal of Respiratory and Critical Care Medicine
Idiopathic pulmonary fibrosis (IPF) is a chronic fatal lung disease with dismal prognosis and no cure. The potential role of the ubiquitously expressed SH2 domain-containing tyrosine phosphatase-2 (SHP2) as a therapeutic target has not been studied i
Autor:
Takahiro Nakajima, Caroline A. Owen
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 185:1137-1139
Chronic obstructive pulmonary disease (COPD) is characterized by an abnormal lung inflammatory response to inhaled noxious particles or gas including those present in cigarette smoke. Patients with COPD can have destructive processes (airspace enlarg
Autor:
John J. Reilly, Scott J. Swanson, Steven J. Mentzer, Ron Vin, Robert L. Berger, Heike Keuhn, Edward P. Ingenito, Andrew M. Hoffman
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 164:295-301
Lung volume reduction surgery (LVRS), the removal of damaged, hyperexpanded lung, has been shown to improve respiratory function in many patients with end-stage emphysema. We report the results of an animal study using a new transbronchoscopic altern
Autor:
Robert A. deLemos, Steven R. Seidner, Jacqueline J. Coalson, Funmei Yang, Vicki T. Winter, Richard J. King, Jeffrey A. Whitsett
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 151:854-866
The surfactant protein secretory cells in airway and alveolar epithelium were studied in premature baboons with bronchopulmonary dysplasia and superimposed infection. PRN animals were delivered by hysterotomy at 140 d gestational age and ventilated o
Autor:
Nobuaki Miyahara, Anthony Joetham, Taku Kodama, Azzeddine Dakhama, Jung Won Park, Katsuyuki Takeda, Christian Taube, Eun Seok Yang, Erwin W. Gelfand, Toshiyuki Koya
Publikováno v:
American journal of respiratory and critical care medicine. 173(1)
There is conflicting information about the development and resolution of airway inflammation and airway hyperresponsiveness (AHR) after repeated airway exposure to allergen in sensitized mice.Sensitized BALB/c and C57BL/6 mice were exposed to repeate
Autor:
Josef Vogt, Karen M. Rieger, Jens Adler, Thomas Iber, Karl Träger, Robert Grover, Ulrich Wachter, Michael Georgieff, Arnim Vlatten, Peter Radermacher, Borislav Santak
Publikováno v:
American journal of respiratory and critical care medicine. 159(6)
We compared the effects of norepinephrine (NOR; n = 11) and the nonselective nitric oxide synthase inhibitor Nomega-monomethyl-L-arginine (L-NMMA; n = 11) on hepatic blood flow (Q liv), O2 exchange, and energy metabolism over 24 h of hyperdynamic, no
Autor:
Susanne Krauss-Etschmann, Alessandra Mossina, Tobias Straub, Oliver Vosyka, Dorothee Brech, Petra Nathan, Darcy E. Wagner, Rudolf Hatz, Hermen S. Overkleeft, Ivan O. Rosas, Elfriede Noessner, Gerhard Preissler, Ali Önder Yildirim, Hauke Winter, Ilona Kammerl, Antje Prasse, Thomas M. Conlon, Oliver Eickelberg, Melanie Königshoff, Katharina Heinzelmann, Christina Lukas, Angela Dann, Silke Meiners, Michael Lindner, Jürgen Behr
Publikováno v:
American journal of respiratory and critical care medicine
American journal of respiratory and critical care medicine, 193(11), 1230-1241
American journal of respiratory and critical care medicine, 193(11), 1230-1241
RATIONALE\nChronic obstructive pulmonary disease patients and in particular smokers are more susceptible to respiratory infections contributing to acute exacerbations of disease. The immunoproteasome is a specialized type of proteasome destined to im
Autor:
Leon A. Metlay, Gloria S. Pryhuber, Sorachai Srisuma, Diana Go, Heidi L. Huyck, Valerie Lunger, Daria Krenitsky, Siva Kumar Solleti, Thomas J. Mariani, Soumyaroop Bhattacharya, Susan E. Wert
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 186:349-358
Bronchopulmonary dysplasia (BPD) is a major complication of premature birth. Risk factors for BPD are complex and include prenatal infection and O(2) toxicity. BPD pathology is equally complex and characterized by inflammation and dysmorphic airspace
Autor:
Valérie F. J. Quesniaux, Louis Fauconnier, Lizette Fick, Bernhard Ryffel, Nicolas Riteau, Marion Couegnat, Isabelle Couillin, Bruno Crestani, Aurélie Gombault, Paméla Gasse, Jean Kanellopoulos, Sylvain Marchand-Adam
Publikováno v:
American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2010, 182 (6), pp.774-83. ⟨10.1164/rccm.201003-0359OC⟩
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2010, 182 (6), pp.774-83. ⟨10.1164/rccm.201003-0359OC⟩
International audience; RATIONALE: Pulmonary fibrosis is a devastating as yet untreatable disease. We previously investigated the endogenous mediators released on lung injury and showed that uric acid is a danger signal activating Nod-like receptor f