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Autor:
Børge G. Nordestgaard, Jonathan Lam, Stewart J. Levine, Maryann Kaler, Xianglan Yao, Jing-Ping Lin, Meixia Gao, Gyorgy Csako, Xuan Qu, Robert D. Shamburek, Zu-Xi Yu, Cuilian Dai, Neal Jeffries, Morten Dahl, Alan T. Remaley, Gayle Z. Nugent, Karin Fredriksson, Karen J. Keeran, Rene Costello
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 302(2)
Apolipoprotein E (apoE) is an endogenous negative regulator of airway hyperreactivity (AHR) and mucous cell metaplasia in experimental models of house dust mite (HDM)-induced airway disease. The gene encoding human apoE is polymorphic, with three com