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Autor:
Fermín Sánchez de Medina, Olga Martínez-Augustin, María Arredondo-Amador, Raquel González, Carlos J. Aranda
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 321(6)
The glucocorticoid receptor NR3C1 is expressed in multiple cell types in the gut and elsewhere. Intestinal epithelial cells both produce and respond to glucocorticoids in different physiological and pathological contexts. In experimental colitis gluc
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 320(6)
Mitochondria damage exacerbates NAFLD through trigerring AIM2 inflammasome activation and hepatocyte pyroptosis. This study provides novel insights into the underlying mechanisms of mitochondrial DNA synthesis in NAFLD and also suggests potential the
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 318(6)
Trypsinogen activation is the hallmark of acute pancreatitis (AP) independent of intra-acinar NF-κB activation and inflammation. We previously found that dopamine (DA) receptor 2 (DRD2) activation controls inflammation during AP via PP2A-dependent N
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Esophageal injury from acid exposure related to gastroesophageal reflux disease is a common problem and a risk factor for development of Barrett’s esophagus and esophageal adenocarcinoma. Our previous work highlights the benefits of using porcine e
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Liver resection induces robust liver regrowth or regeneration to compensate for the lost tissue mass. In a clinical setting, pregnant women may need liver resection without terminating pregnancy in some cases. However, how pregnancy affects maternal
Autor:
Aneta Targosz, Aleksandra Szlachcic, Anna Chmura, Gracjana Krzysiek-Maczka, Tomasz Brzozowski, Dominik Bakalarz, Jolanta Majka, Katarzyna Magierowska, Agata Ptak-Belowska, Marcin Magierowski, Katarzyna Urbanczyk, Mateusz Wierdak
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 318(3)
Mixed acidic-alkaline refluxate is a major pathogenic factor in chronic esophagitis progressing to Barrett's esophagus (BE). We hypothesized that epidermal growth factor (EGF) can interact with COX-2 and peroxisome proliferator-activated receptor-γ
Autor:
Boye L. Jensen, Signe Wiese, Annette Dam Fialla, Aleksander Krag, Bjørn Stæhr Madsen, Emilie Kristine Dahl, Sören Möller, Flemming Bendtsen, Mads Israelsen
Publikováno v:
Israelsen, M, Dahl, E K, Madsen, B S, Wiese, S, Bendtsen, F, Møller, S, Fialla, A D, Jensen, B L & Krag, A 2020, ' Dobutamine reverses the cardio-suppressive effects of terlipressin without improving renal function in cirrhosis and ascites : a randomized controlled trial ', American journal of physiology. Gastrointestinal and liver physiology, vol. 318, no. 2, pp. G313-G321 . https://doi.org/10.1152/ajpgi.00328.2019
Acute kidney injury and hepatorenal syndrome (HRS) are frequent complications in patients with cirrhosis and ascites. First-line treatment is terlipressin, which reverses HRS in ~40% of patients but also lowers cardiac output (CO). We aimed to invest
Autor:
Meg Hauer, William Katzka, Enrique Rozengurt, Guido Eibl, Tien S. Dong, Jonathan P. Jacobs, Venu Lagishetty, Hui-Hua Chang
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Pancreatic ductal adenocarcinoma (PDAC)’s growing incidence has been linked to the rise in obesity and type 2 diabetes mellitus. In previous work, we have shown that metformin can prevent the increased incidence of PDAC in a KrasG12D mouse model su
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
The majority of patients with Parkinson’s disease (PD) experience gastrointestinal dysfunction. Recently, we described a nigro-vagal pathway that uses dopaminergic (DA) inputs to the dorsal motor nucleus of the vagus (DMV) and A2 area neurons to mo
Autor:
Baoan Ji, Guowei Zhang, Ashok K. Saluja, Yan Bi, Ashley N. Haddock, Yinghua Li, Jia Guo, Lele Song, Yuebo Zhang, Rajinder Dawra, Fu Gui, Xianbao Zhan, Jianhua Wan, Lizhi Zhang
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Intra-acinar trypsinogen activation occurs in the earliest stages of pancreatitis and is believed to play important roles in pancreatitis pathogenesis. However, the exact role of intra-acinar trypsin activity in pancreatitis remains elusive. Here, we