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Autor:
Ta-Sen Yeh, Puo-Hsien Le, Kun-Chun Chiang, Jun-Te Hsu, Tsung-Hsing Chen, Chia-Jung Kuo, Chun-Jung Lin
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 312(5)
Although melatonin attenuates the increases in inflammatory mediators and reduces organ injury during trauma-hemorrhage, the mechanisms remain unclear. This study explored whether melatonin prevents liver injury after trauma-hemorrhage through the p3
Autor:
Huan Tong, Jinhui Yang, Zhi Yin Huang, Jinhang Gao, Cheng Wei Tang, Ying Mei Tang, Yang Tai, Rui Liu, Zhao Ping Yan, Shi Lei Wen, Chun Hui Wang, Wen Juan Yang, Shi Hang Tang, Cheng Ye
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 310(11)
Inflammatory transport through the gut-liver axis may facilitate liver cirrhosis. Cyclooxygenase-2 (COX-2) has been considered as one of the important molecules that regulates intestinal epithelial barrier function. This study was aimed to test the h
Autor:
Songling Liu, Don C. Rockey
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
The function of the endothelial isoform of nitric oxide synthase (eNOS) and production of nitric oxide (NO) is altered in a number of disease states. Pharmacological approaches to enhancing NO synthesis and thus perhaps endothelial function could hav
Autor:
Kiyoshi Sugiyama, Takashi Ushiki, Ayako Mimura, Kohta Baba, Risako Kon, Wataru Ochiai, Nobutomo Ikarashi, Makoto Ishii, Takahiro Toda
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 301(5)
The purpose of this study was to investigate the role of aquaporin3 (AQP3) in the colon in the laxative effect of bisacodyl. After oral administration of bisacodyl to rats, AQP3, macrophages, cyclooxygenase 2 (COX2), and prostaglandin E2(PGE2) were e
Autor:
S. Novak, Rabban Mangat, Donna F. Vine, James C. Russell, Abdoulaye Diane, Sandra E. Kelly, Ye Wang, Spencer D. Proctor
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 299(2)
Rimonabant (SR141716) is a specific antagonist of the cannabinoid-1 receptor. Activation of the receptor initiates multiple effects on central nervous system function, metabolism, and body weight. The hypothesis that rimonabant has protective effects
Autor:
Satish Rattan
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 298(6)
RhoA prenylation may play an important step in the translocation of RhoA in the basal internal anal sphincter (IAS) smooth muscle tone. Statins inhibit downstream posttranslational RhoA prenylation by 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) r
Autor:
Sushil K. Sarna, Xuan Zheng Shi
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 295(1)
Recent findings show that the enteric neurotransmitter VIP enhances gene transcription of the α1C subunit of Cav1.2 (L-type) Ca2+ channels in the primary cultures of human colonic circular smooth muscle cells and circular smooth muscle strips. In th
Autor:
Minoru Tsukada, Hiroshi Ichikawa, Hisato Tsuboi, Satoshi Kokura, Yuji Naito, Osamu Handa, Tomohisa Takagi, Norimasa Yoshida, Kazuhiro Katada, Toshikazu Yoshikawa
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 292(2)
CXC chemokines, including human interleukin-8 and rat cytokine-induced neutrophil chemoattractant-1, play a crucial role in the pathogenesis of intestinal inflammation induced by ischemia-reperfusion (I-R). Thrombin and its specific receptor, proteas
Autor:
Wim Laleman, Lien Van Landeghem, David Cassiman, Raf Bisschops, Johan Fevery, Jos van Pelt, Frederik Nevens, Tania Roskams, Marcel Zeegers, Ingrid Vander Elst, Tamara Severi
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 292(2)
In chronic liver injury, hepatic stellate cells (HSCs) have been implicated as regulators of sinusoidal vascular tone. We studied the relative role of Ca2+-dependent and Ca2+-independent contraction pathways in rat HSCs and correlated these findings
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 288(2)
α1- and β-Adrenoceptor stimulation elicits Mg2+extrusion from liver cells in conjunction with hepatic glucose output (T. Fagan and A. Romani. Am J Physiol Gastrointest Liver Physiol 279: G943–G950, 2000.). To characterize the role of intrahepatic