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Autor:
Marie-France Langlois, Mathias Alterman, Sandra Pinard, Claude Roberge, Anders Hallberg, Sébastien M. Labbé, Michael Shum, Nicole Gallo-Payet, Charlotta Wallinder, André C. Carpentier, Jean-Patrice Baillargeon, Marie-Odile Guimond
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 304(2)
This study was aimed at establishing whether specific activation of angiotensin II (ANG II) type 2 receptor (AT2R) modulates adipocyte differentiation and function. In primary cultures of subcutaneous (SC) and retroperitoneal (RET) preadipocytes, bot
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 297(5)
The present study attempted to define the role of hepatic Niemann-Pick C1-like 1 (NPC1L1), a cholesterol transporter, in hepatic insulin resistance as well as hepatic steatosis. The inhibition of NPC1L1 and its molecular consequences were examined in
Autor:
Charles Lavigne, Geneviève Pilon, Vanessa P. Houde, Gary Sweeney, Simon Chewchuk, Aimin Xu, Ying Liu, Sophie Brûlé, André Marette
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 297(3)
Endocrine effects of adipose-derived adiponectin on skeletal muscle have been shown to account, at least in part, for the anti-diabetic effects of this adipokine. Recently, the concept of myokines has gained credence, and the potential for skeletal m
Autor:
Resat Unal, Irina D. Pokrovskaya, Preeti Tripathi, Philip A. Kern, Anannya Banga, Gouri Ranganathan, Randall J. Owens
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 296(3)
Adiponectin, made exclusively by adipocytes, is a 30-kDa secretory protein assembled posttranslationally into low-molecular weight, middle-molecular weight, and high-molecular weight homo-oligomers. PPARγ ligand thiozolidinediones, which are widely
Autor:
Mauren F. A. Livak, Denis C. Muller, Michel Bernier, Josephine M. Egan, Olga D. Carlson, Dariush Elahi, Jie Zhou, Stuart Maudsley
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 293(2)
Glucose-dependent insulinotropic polypeptide (GIP) is a gastrointestinal hormone that has a potent stimulatory effect on insulin release under conditions of normal glucose tolerance. However, its insulinotropic effect is reduced or even absent entire
Publikováno v:
Vrije Universiteit Brussel
Pancreatic β-cells are the major extraneural site of glutamate decarboxylase expression (GAD). During culture of isolated β-cells, the GAD product γ-aminobutyrate (GABA) is rapidly released in the medium, independently of insulin. It is considered
Autor:
May-Yun Wang, Roger H Unger
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 288(1)
In obese rodents, excess myocardial lipid accumulation (lipotoxicity) of myocardium may cause cardiomyopathy that in the obese Zucker diabetic fatty (ZDF) fa/fa rat can be prevented by treatment with troglitazone (TGZ). To determine the underlying me
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 280(4)
Pituitary folliculostellate cells (FSCs) are thought to partially inhibit pituitary hormone secretion through a paracrine mechanism. In this process, one of the important questions is what factors regulate the function of FSCs. Because ACh is synthes