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Publikováno v:
American Journal of Physiology-Renal Physiology. 311:F94-F102
Cisplatin, a wildly used chemotherapy drug, induces nephrotoxicity that is characterized by renal tubular cell apoptosis. In response to toxicity, tubular cells can activate cytoprotective mechanisms, such as the heat shock response. However, the rol
Publikováno v:
American Journal of Physiology-Renal Physiology. 309:F474-F483
Because cyclophosphamide-induced hyponatremia was reported to occur without changes in plasma vasopressin in a patient with central diabetes insipidus, we hypothesized that cyclophosphamide or its active metabolite, 4-hydroperoxycyclophosphamide (4-H
Autor:
Masanori Tokumoto, Narihito Tatsumoto, Takanari Kitazono, Shunsuke Yamada, Kohsuke Masutani, Toshiaki Nakano, Masatomo Taniguchi, Hiroaki Ooboshi, Kazuhiko Tsuruya, Hideko Noguchi
Publikováno v:
American Journal of Physiology-Renal Physiology. 306:F1418-F1428
Hyperphosphatemia contributes to increased cardiovascular mortality through vascular calcification (VC) in patients with chronic kidney disease (CKD). Malnutrition and inflammation are also closely linked to an increased risk of cardiovascular death
Autor:
David A. Vesey, Paul B. Colditz, Lindsay Brown, Glenda C. Gobe, Nigel C. Bennett, Malcolm J. West, David W. Johnson
Publikováno v:
American Journal of Physiology-Renal Physiology. 306:F681-F692
Treatment of renal ischemia-reperfusion (IR) injury with recombinant human erythropoietin (rhEPO) reduces acute kidney injury and improves function. We aimed to investigate whether progression to chronic kidney disease associated with acute injury wa
Autor:
Laureano D. Asico, Xi Lu, Shuo Zheng, Hongyong Wang, Duofen He, Wei Eric Wang, Hongmei Ren, Chunyu Zeng, Cai Yu Chen, Jian Yang, Pedro A. Jose, Shaoxiong Wang, Yu Han, Lin Zhou
Publikováno v:
American Journal of Physiology-Renal Physiology. 306:F588-F596
The dopaminergic and sympathetic systems interact to regulate blood pressure. Our previous studies showed regulation of α1-adrenergic receptor function by D1-like dopamine receptors in vascular smooth muscle cells. Because renalase could regulate ci
Autor:
Robert H. Henning, Maaike Goris, Hendrik Buikema, Leo E. Deelman, M Duin, Azuwerus van Buiten, Magdalena Mazagova, Maria Sandovici
Publikováno v:
American journal of physiology-Renal physiology, 305(9), F1249-F1264. AMER PHYSIOLOGICAL SOC
Growth differentiation factor 15 (GDF15) is emerging as valuable biomarker in cardiovascular disease and diabetic kidney disease. Also, GDF15 represents an early response gene induced after tissue injury and studies performed in GDF15 knockout (KO) m
Autor:
Kook Hwan Oh, Curie Ahn, Hwajung Kim, Jaeseok Yang, Eun Kyoung Shin, Hyosang Kim, Kyung Don Ju, Eun Jin Cho, Young Hwan Hwang, Hyun Bae Yoon
Publikováno v:
American Journal of Physiology-Renal Physiology. 302:F606-F613
Pyruvate is an endogenous antioxidant and anti-inflammatory substance. The present study was implemented to investigate the protective effect of ethyl pyruvate (EP) against the development and progression of diabetic nephropathy in an in vivo and in
Autor:
Noriyuki Sakurai, Takashi Kuroiwa, Masaaki Miya, Keiichiro Mishima, Hideaki Yokoo, Hidekazu Ikeuchi, Yoshihisa Nojima, Keiju Hiromura, Akito Maeshima
Publikováno v:
American Journal of Physiology-Renal Physiology. 301:F387-F395
Renal proximal tubular epithelium can regenerate after various insults. To examine whether the tubular repair process is regulated by surrounding peritubular capillaries, we established an in vitro human tubulogenesis model that mimics in vivo tubula
Publikováno v:
American Journal of Physiology-Renal Physiology. 299:F49-F54
Prolactin is a natriuretic hormone and acts by inhibiting the activity of renal tubular Na+-K+-ATPase activity. These effects require an intact renal dopamine system. Here, we have studied by which mechanism prolactin and dopamine interact in Sprague
Publikováno v:
American Journal of Physiology-Renal Physiology. 298:F426-F434
Glomerular mesangial cells (MCs) proliferate and produce extracellular matrix proteins in many progressive renal diseases. Recently, histone deacetylase inhibitors (HDIs) were shown to have antiproliferative and antifibrogenic effects in some in vitr