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Publikováno v:
Am J Physiol Renal Physiol
Extracellular proteases can activate the epithelial Na channel (ENaC) by cleavage of the γ subunit. Here, we investigated the cleavage state of the channel in the kidneys of mice and rats on a low-salt diet. We identified the cleaved species of chan
Autor:
Shan Chen, Hui Tang, Chun Zhang, Zheng Zhao, Jiao Zhang, Fang-Fang He, Hua Su, Yu-Mei Wang, Chao-Qun You, Chen Ye, Pan Gao, Chun-Tao Lei
Publikováno v:
American Journal of Physiology-Renal Physiology. 312:F760-F768
It is well recognized that murine double minute gene 2 (MDM2) plays a critical role in cell proliferation and inflammatory processes during tumorigenesis. It is also reported that MDM2 is expressed in glomeruli and involved in podocyte injury. Howeve
Publikováno v:
American Journal of Physiology-Renal Physiology. 312:F278-F283
Diabetes mellitus is associated with decreased nitric oxide bioavailability thereby affecting renal blood flow regulation. Previous reports have demonstrated that cellular uptake of l-arginine is rate limiting for nitric oxide production and that pla
Autor:
Elisa B.M.I. Peixoto, José B. Lopes de Faria, Cynthia M. Borges, Kamila C. Silva, Jacqueline M. Lopes de Faria, Alexandros Papadimitriou
Publikováno v:
American Journal of Physiology-Renal Physiology. 308:F209-F225
Reduction in sirtuin 1 (Sirt-1) is associated with extracellular matrix (ECM) accumulation in the diabetic kidney. Theobromine may reduce kidney ECM accumulation in diabetic rats. In the current study, we aimed to unravel, under diabetic conditions,
Publikováno v:
American Journal of Physiology-Renal Physiology. 305:F1265-F1276
Numerous proinflammatory cytokines have been implicated in the reorganization of lower urinary tract function following cyclophosphamide (CYP)-induced cystitis. The present study investigated the functional profile of three pleiotropic transforming g
Autor:
Maria Heloisa Massola Shimizu, Lucia Andrade, Camila E. Rodrigues, Ana Clara de Souza, Talita Rojas Sanches, Rildo Aparecido Volpini, Patricia Semedo, Antonio Carlos Seguro, Niels Olsen Saraiva Camara
Publikováno v:
American Journal of Physiology-Renal Physiology. 302:F1045-F1054
The pathophysiology of sepsis involves complex cytokine and inflammatory mediator networks, a mechanism to which NF-κB activation is central. Downregulation of endothelial nitric oxide synthase (eNOS) contributes to sepsis-induced endothelial dysfun
Autor:
Kook Hwan Oh, Curie Ahn, Hwajung Kim, Jaeseok Yang, Eun Kyoung Shin, Hyosang Kim, Kyung Don Ju, Eun Jin Cho, Young Hwan Hwang, Hyun Bae Yoon
Publikováno v:
American Journal of Physiology-Renal Physiology. 302:F606-F613
Pyruvate is an endogenous antioxidant and anti-inflammatory substance. The present study was implemented to investigate the protective effect of ethyl pyruvate (EP) against the development and progression of diabetic nephropathy in an in vivo and in
Autor:
Hiromitsu Matsui, Toshiro Fujita, Kazuhiko Muraoka, Ai Nagae, Chiaki Kawarasaki, Katsuyuki Ando, Megumi Fujita, Hiroo Kawarazaki
Publikováno v:
American Journal of Physiology-Renal Physiology. 300:F1402-F1409
Excessive salt intake is known to preferentially increase blood pressure (BP) and promote kidney damage in young, salt-sensitive hypertensive human and animal models. We have suggested that mineralocorticoid receptor (MR) activation plays a major rol
Autor:
Alberto Gonzalez-Menchen, Sagrario Cañadillas, Rosa Ortega, Carlos Pérez-Seoane, Jeronimo Egea, Alejandro Martin-Malo, María López-Andreu, Rafael J. Ramirez, J. C. Estepa, Ciro Tetta, Pedro Aljama, Mariano Rodriguez
Publikováno v:
American Journal of Physiology-Renal Physiology. 299:F1278-F1287
Recent studies have demonstrated that erythropoietin (EPO) and its analogs induce cytoprotective effects on many nonerythroid cells. In this study, we examined whether darbepoetin-α might prevent glomerular lesions in the Thy-1.1 model of glomerulon
Autor:
Aurélie Edwards, Whaseon Lee-Kwon, Mauricio Sendeski, Lan Cui, Andreas Patzak, Chun Yu Cai, Chunhua Cao, Thomas L. Pallone
Publikováno v:
American Journal of Physiology-Renal Physiology. 299:F1056-F1064
Descending vasa recta (DVR) are 12- to 15-μm microvessels that supply the renal medulla with blood flow. We examined the ability of intrinsic nitric oxide (NO) and reactive oxygen species (ROS) generation to regulate their vasoactivity. Nitric oxide